Effect of Scutellaria Extract to Cytochrome P450 Enzymes
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Effect of Scutellaria Extract to Cytochrome P450 Enzymes
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 2, Pages: 202-205(2012)
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Published:2012
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YAO Jue-cheng, NI Jian, HAN Jing, et al. Effect of Scutellaria Extract to Cytochrome P450 Enzymes[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(2): 202-205.
DOI:
YAO Jue-cheng, NI Jian, HAN Jing, et al. Effect of Scutellaria Extract to Cytochrome P450 Enzymes[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(2): 202-205.DOI:
Effect of Scutellaria Extract to Cytochrome P450 Enzymes
Objective: To study the effect of Scutellaria extract to cytochrome P450 enzymes CYP1A2 CYP3A4
CYP2E1 and CYP2C19. Method: To establish an RP-HPLC method for the study of 4 probe drugs in rats plasma. The rats are divided in 2 groups randomly. One group were given Scutellaria extract once daily
another received normal saline once daily as the blank control. After 10 days of treatment
the rats were given 4 probe drugs by tail intravenous injection and the plasma were obtained at 0
5
10
15
30
15
60
180
360
540
720 min. The plasma concentration of 4 probe drugs was determined by RP-HPLC. The pharmacokinetic parameters were calculated by Kinetica 5.0. Result: The metabolism of dapsone
chlorzoxazone and omeprazole are slowed down significantly while the T1/2of all 4 probe drugs were increased. The MRT0→∞of chlorzoxazone and omeprazole were increased significantly. Conclusion: Scutellaria extract tended to be the inhibitor of CYP1A2
CYP3A4
CYP2E1 and CYP2C19. But CYP3A4 and CYP2E1 were affected significantly.
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