Study on Quality Standard for Shangshizhitong Plaster based on Hot-Melt Pressure Sensitive Adhesives

YAN Xiao-ping; ZHENG Rui; GUAN Shi-jie; YI Bo-wen; LI Li

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Study on Quality Standard for Shangshizhitong Plaster based on Hot-Melt Pressure Sensitive Adhesives

更新时间：2024-01-04

- Study on Quality Standard for Shangshizhitong Plaster based on Hot-Melt Pressure Sensitive Adhesives
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 6, Pages: 66-68(2012)
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- Published：2012
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YAN Xiao-ping, ZHENG Rui, GUAN Shi-jie, et al. Study on Quality Standard for Shangshizhitong Plaster based on Hot-Melt Pressure Sensitive Adhesives[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(6): 66-68.
DOI：

YAN Xiao-ping, ZHENG Rui, GUAN Shi-jie, et al. Study on Quality Standard for Shangshizhitong Plaster based on Hot-Melt Pressure Sensitive Adhesives[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(6): 66-68. DOI：

摘要

目的: 建立伤湿止痛热熔压敏贴膏的质量控制方法。方法: 采用薄层色谱法对伤湿止痛热熔压敏贴膏中颠茄流浸膏进行定性鉴别;采用高效液相色谱法对贴膏中马钱子碱和士的宁进行含量测定。结果: 在薄层色谱中能检出颠茄流浸膏中硫酸阿托品的特征斑点;高效液相色谱法测定贴膏中马钱子碱和士的宁的含量

士的宁在0.53~53.0 mg·L-1线性关系良好(r=0.999 5)

其平均回收率为95.57%

RSD 2.91% (n=6);马钱子碱在0.50~50.0 mg·L-1线性关系良好(r=0.999 5)

其平均回收率为97.95%

RSD 1.43% (n=6)。结论: 方法简便、专属性强、重复性好

可用于控制伤湿止痛热熔压敏贴膏的质量。

Abstract

Objective: To establish the quality control standard of Shangshizhitong plaster based on hot-melt pressure sensitive adhesives. Method: Belladonna Liquid Extract in Shangshizhitong plaster was identified by TLC. The content of brucine and strychnine in Shangshizhitong plaster was identified by HPLC. Result: Atropine in belladonna liquid extract could be detected by TLC. Strychnine shows a good linear relationship in the range of 0.53-53.0mg·L-1(r=0.999 5)

which average recovery was 95.57% and RSD was 2.91% (n=6). Brucine shows a good linear relationship in the range of 0.53-53.0mg·L-1(r=0.999 5)

whose average recovery was 97.95% and RSD was 1.43% (n=6). Conclusion: The method was simple

specific and accurate. This study provide a method for the quality control of Shangshizhitong plaster based on hot-melt pressure Sensitive Adhesives.

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Related Author

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Related Institution

Department of Pharmacy,Nanjing University of Chinese Medicine

Institution of Clinical Pharmacology,the Affiliated Drum Tower Hospital of Nanjing University Medical School

Institute of Cinese Materia Medica,China Academy of Chinese Medical Scineces

中国中医科学院中药研究所北京100700

Nanjing University of Traditionanl Chinese Medicine

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