Experimental Study on Anti-tumor Effect of the Total Saponins from the Crude and Processed Products of

DENG Wu-hong; XIAO Er; XIONG Hui; MO Sha-sha; MEI Zhi-nan

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Experimental Study on Anti-tumor Effect of the Total Saponins from the Crude and Processed Products of

更新时间：2024-01-04

- Experimental Study on Anti-tumor Effect of the Total Saponins from the Crude and Processed Products of
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 6, Pages: 148-150(2012)
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- Published：2012
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DENG Wu-hong, XIAO Er, XIONG Hui, et al. Experimental Study on Anti-tumor Effect of the Total Saponins from the Crude and Processed Products of [J]. Chinese journal of experimental traditional medical formulae, 2012, 18(6): 148-150.
DOI：

DENG Wu-hong, XIAO Er, XIONG Hui, et al. Experimental Study on Anti-tumor Effect of the Total Saponins from the Crude and Processed Products of [J]. Chinese journal of experimental traditional medical formulae, 2012, 18(6): 148-150. DOI：

摘要

目的: 考察榼藤子生品和炮制品总皂苷体内抗肿瘤作用。方法: 荷瘤小鼠随机分为8组

接种后第2天给药

连续10 d

模型对照组ig以等量生理盐水

阳性对照组腹腔注射顺铂3 mg·kg-1

低、中、高剂量榼藤子生品、炮制品总皂苷组分别ig 0.25

0.5

1 g·kg-1剂量。观察榼藤子总皂苷的肿瘤抑制作用;计算抑瘤率、胸腺指数、脾指数、肝脏指数;测定血清超氧化物歧化酶(SOD)、丙二醛(MDA)水平。结果: 榼藤子生品高、中、低剂量组的抑瘤率分别为58.86%

49.52%

43.45%

榼藤子炮制品高、中、低剂量组的抑瘤率分别为59.41%

48.81%

44.59%

榼藤子生品及炮制品总皂苷还能提升荷瘤小鼠血清SOD的活力

降低MDA水平。结论: 榼藤子生品和炮制品总皂苷具有抗小鼠肿瘤作用

并可增强抗氧化能力。

Abstract

Objective: To study the anti-tumor action of total saponins from the crude and processed products of Entada phaseoloides in vivo. Method: Mice bearing transplanted tumor S180 were used to observe the effects of total saponins from E. phaseoloides;then inhibition ratio

thymus index

spleen index and liver index were calculated. The 1eve1 of superoxide dismutase (SOD) and malondialdehyde (MDA) was detected. Result: The crude and processed products E. phaseoloides saponins showed a significant anti-cancer activity on S180 implanted in mice

increased the level of SOD and reduced the content of MDA in blood serum in tumor-bearing mice. Conclution: The crude and processed products E. phaseoloides saponins have anti-tumor effects and anti oxidative capacity.

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Related Institution

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