The Effects of Danggui Beimu Kushen Decoction on TNF- in Prostates in Rats with Chronic Baterial Prostatitis

HE Li-qing; FU Yan-ling; MA Yan-hong; CAO Feng; LIU Xiao-he

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The Effects of Danggui Beimu Kushen Decoction on TNF- in Prostates in Rats with Chronic Baterial Prostatitis

更新时间：2024-01-04

- The Effects of Danggui Beimu Kushen Decoction on TNF- in Prostates in Rats with Chronic Baterial Prostatitis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 2, Pages: 212-214(2012)
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- Published：2012
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HE Li-qing, FU Yan-ling, MA Yan-hong, et al. The Effects of Danggui Beimu Kushen Decoction on TNF- in Prostates in Rats with Chronic Baterial Prostatitis[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(2): 212-214.
DOI：

HE Li-qing, FU Yan-ling, MA Yan-hong, et al. The Effects of Danggui Beimu Kushen Decoction on TNF- in Prostates in Rats with Chronic Baterial Prostatitis[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(2): 212-214. DOI：

摘要

目的: 观察当归贝母苦参煎剂对慢性细菌性前列腺炎(CBP)大鼠前列腺组织中肿瘤坏死因子-α(TNF-α)的免疫组化和mRNA表达的影响

探讨其可能的作用机制。方法: 雄性SD大鼠60只

随机分为空白对照组、模型组、诺氟沙星组、当归贝母苦参煎剂高、中、低剂量组6组

每组10只

前列腺背叶注射大肠埃希菌制备CBP动物模型。当归贝母苦参煎剂高、中、低剂量分别为11.67

5.83

2.92 g·kg-1

诺氟沙星剂量为9.3×10-2 g·kg-1。术后第15天起用药

连续4周。用免疫组化法观测大鼠前列腺组织中的TNF-α表达

用RT-PCR法测大鼠前列腺组织TNF-α mRNA的表达。结果: 与模型组比较

当归贝母苦参煎剂各剂量组TNF-α免疫组化阳性表达和mRNA基因表达均明显降低(P<0.01)

其中高剂量组最低。结论: 当归贝母苦参煎剂治疗慢性细菌性前列腺炎的作用机制可能与减少TNF-α的产生有关。

Abstract

Objective: To observe the effects of Danggui Beimu Kushen(DGBMKS) decoction on tumor necrosis factor-α(TNF-α) in the prostates of chronic bacterial prostatitis(CBP) rats and investigate the mechanism. Method: Sixty male SD rats were randomly divided into 6 groups(10 each):control group

the model group

western medicine group

high

middle and low-dose groups of DGBMKS decoction.The CBP model was established by injecting E.coli into the dorsal lobes of the prostate.High

medium and low doses of DGBMKS decoction were 11.67

5.83

2.917 g·kg-1

and norfloxacin dose was 9.3 g·kg-1.Drugs were given on the 15th day after operation for 4 weeks.The expression of TNF-α and its mRNA in the prostates of rats were measured. Result: Compared to the model group

the expression of TNF-α and its mRNA were significantly decreased in the high

middle and low-dose groups of DGBMKS decoction(P<0.01)

especially most decreased in the high-group. Conclusion: The mechanism of DGBMKS decoction treating CBP may be related to reducing the production of TNF-α in CBP rats.

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