Objective: To observe the effects of Yangxinkang tablet on cardiac function

tumor necrosis factor-α(TNF-α) and interleunin-6(IL-6) in rabbit with chronic heart failure. Method: The rabbit heart failure animal model was established by blocking left anterior descending coronary artery. The rabbits were randomly divided into model group

captopril group

low dose group

middle dose group and high dose group of Yangxinkang tablet

the normal control group was set

with 5 rabbits in each group. After 5days of modelling

captoprilat dose of 1.2 mg·kg-1and Yangxinkang tablet at dosage of 0.17

0.51

1.53 g·kg-1were orally administrated once a day for 4 weeks. The effects of Yangxinkang tablet on cardiac function

TNF-α and IL-6 were investgated. Result: The left ventricular end diastolic volum(LVEDV) in control group was lowest(2.20±1.14)mL

compared with model group (4.12±1.19)mL

the difference was statistically significant(P<0.01)

and compared with model group

middle dose group

high dose group and captopril group showed satistically significant (P<0.05). LVEF was 64.80%±12.07% in model group

middle dose group and high dose group indicated statistically significant(P<0.01)

compared with model group.The level of TNF-α and IL-6 in the model group was highest

the differences in Yangxinkang tablet groups and captopril were statistically significant compared with model group (P<0.01). Conclusion: Yangxinkang tablet can improve cardiac function

reduce serum TNF-α and IL-6 levels in rabbits with heart failure.