Objective : To explore primary Chinese and western medicines treating chronic hepatitis B and their combination regularity with text mining technique. Method : Literatures on Chinese and western medicines treating chronic hepatitis B were collected from Chinese biomedical literature database (CBM) and access database was established. Above data were processed by SQL

meanwhile

data noise was removed with artificial means. And then

primary Chinese and western medicines treating chronic hepatitis B and their combination regularity were received by text mining technique. Result: Chinese herbs

such as salvia

astragalus

bupleurum

polygonum

licorice

matrine

aspartame

capillaries and gardenia

were main components of Chinese herb compound treating chronic hepatitis B. Danshen injection and interferon were the most commonly used Chinese patent medicine and western medicine for chronic hepatitis B. Some western medicine

for example

Interferon

lamivudine

thymosin

glutathione and vitamin C were often used in combination with Danshen injection. In addition

lamivudine was applied with astragalus injection

yiganling

hugan slices or gansu particles. Conclusion : Primary application of Chinese and western medicines treating chronic hepatitis B and their combination regularity not only reflect clinical practical state

but also expanded the scopes and thingking of clinical application of Chinese and western medicine.