Protective Effect of Arctinin Capsule on the Nephrotic Rat Induced by Adriamycin

LI Jun; DONG Xin-xin; LUO Ying-ying; LIANG Bin; CHEN Lan-ying

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Protective Effect of Arctinin Capsule on the Nephrotic Rat Induced by Adriamycin

更新时间：2024-01-04

- Protective Effect of Arctinin Capsule on the Nephrotic Rat Induced by Adriamycin
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 7, Pages: 160-163(2012)
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- Published：2012
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LI Jun, DONG Xin-xin, LUO Ying-ying, et al. Protective Effect of Arctinin Capsule on the Nephrotic Rat Induced by Adriamycin[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(7): 160-163.
DOI：

LI Jun, DONG Xin-xin, LUO Ying-ying, et al. Protective Effect of Arctinin Capsule on the Nephrotic Rat Induced by Adriamycin[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(7): 160-163. DOI：

摘要

目的: 研究牛蒡苷胶囊对阿霉素肾病大鼠的保护作用。方法: 采用一次性尾静脉注射(阿霉素ADR)复制微小病变型肾病模型

。SD雄性大鼠随机分为空白组、模型组、阳性药醋酸泼尼松片5 mg·kg-1组、牛蒡苷胶囊高、中、低剂量组(767

383

192 mg·kg-1)

ig给药6周。于每周末将大鼠放入代谢笼中

收集24 h尿液

用全自动生化仪测定尿蛋白含量。于末次给药后24 h

眼眶静脉丛采血

于全自动生化仪测定白蛋白(ALB)、甘油三酯(TG)、胆固醇(TC)含量;采用酶联免疫法测定血清转化生长因子-β1(TGF-β1 )水平;采用黄嘌呤氧化酶法和硫代巴比妥法分别测定血清超氧化物歧化酶(SOD)和丙二醛(MDA);肾组织病理学检测。结果: 与模型组比较

牛蒡苷胶囊高、中剂量能减少阿霉素肾病大鼠的尿蛋白含量

提高血清ALB含量;牛蒡苷胶囊3个剂量组能降低血清TG和TGF-β1含量;牛蒡苷高剂量(767 mg·kg-1)能提高血清SOD活性、降低血清MDA含量;牛蒡苷胶囊3个剂量组能够促进肾组织病理改变的修复。结论: 牛蒡苷胶囊对阿霉素肾病大鼠的保护作用可能与其清除氧自由基、抑制脂质过氧化反应、抑制肾小球纤维化等作用有关。

Abstract

Objective: To study the protective effect of arctinin capsule on the nephritic rat induced by adriamycin (ADR). Method: Minimal change nephrotic rat model was induced by intravenous injection of ADR

male SD rat were randomly divided into 6 groups:Blank group

Model group

positive group

arctinin capsule high-dose group(767 mg·kg-1)

middle-dose group(383 mg·kg-1)and low-dose group(192 mg·kg-1)

treated for 6 weeks. Result: Campared with the rats in model group

arctinin capsule high-dose

middle-dose could reduced the proteinuria of the nephritic rat induced by adriamycin

increase the level of serum albumin(ALB);Arctinin capsule all the 3 doses could cut down the level of serum triglyeride(TG)and transforming growth factor-β1 (TGF-β1); Arctinin capsule high-dose(767 mg·kg-1) could increase the level of serum superoxide dismutase (SOD)and cut down the level of serum malondialdehyde (MDA);at the same time

arctinin capsule all the 3 doses could significanty ameliorated the change of pathology in renal. Conclusion: The protective action of arctinin capsule on the nephritic rat induced by adriamycin may be related to the purification on free-radical

the inhibition of lipid peroxidation and glomerular fibrosis.

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Related Institution

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School of Pharmacy，Anhui University of Chinese Medicine & Laboratory of Rearch and Development of Traditional Chinese Medicine in Anhui Province

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