Experimental Studies on the Anti-type-Ⅰ Hypersensitivity of Guizhi Jia Gegen Tang
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Experimental Studies on the Anti-type-Ⅰ Hypersensitivity of Guizhi Jia Gegen Tang
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 5, Pages: 194-196(2012)
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Published:2012
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ZHAO Yu-tang. Experimental Studies on the Anti-type-Ⅰ Hypersensitivity of Guizhi Jia Gegen Tang[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(5): 194-196.
DOI:
ZHAO Yu-tang. Experimental Studies on the Anti-type-Ⅰ Hypersensitivity of Guizhi Jia Gegen Tang[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(5): 194-196.DOI:
Experimental Studies on the Anti-type-Ⅰ Hypersensitivity of Guizhi Jia Gegen Tang
Objective: To study the effects and pharmacological mechanism of anti-type-I hypersensitivity of Guizhi Jia Gegen Tang(GGT). Method: Mice were randomized into six groups
the control
chlorpheniramine
dehydrocortisone and low
moderate
high dosage of GGT. Using the type- I hypersensitivity animal model
the effects of six groups on the passive cutaneous hypersensitivity and capillary permeability were compared. Result: Administration of GGT attenuated significantly the diameter of blue plaque induced by the anti-serum with different dilution(P<0.01)
of which both the moderate and high dosage of GGT have similar potency of chlorpheniramine. The increase of capillary permeability induced by 5-hydroxytryptamine or histamine and the voix pedis swell evoked by histamine were counteracted by all the three dosages of GGT (P<0.01) alike chlorpheniramine. Conclusion: The antagonism against the mediators of inflammation may contributed to the anti-type-I hypersensitivity of GGT.
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