Objective: To observe the protective effect and mechanism of breviscapine on cisplatin-induced nephrotoxicity in mice. Method: The mice were randomly divided into four groups: control group

model group

breviscapine group treated by 25 mg ·kg-1(LBTG) and breviscapine group treated by 50 mg ·kg-1(HBTG). Other three groups were treated by a single injection of cisplatin(8 mg ·kg-1) ip to establish model except control group

then the mice in LBTG and HBTG were given different dose of breviscapine (25

50 mg ·kg-1

ig) once a day for seven days. The renal tissue and change of BUN and SCr in their serum were observed. The change of SOD or MDA in there serum and renal cortex homogenate was also determined. Result: Serious damage in renal tissue was found

level of BUN and SCr was increased

and the content of MDA was increased

but the activity of SOD declined in serum and renal cortex homogenate in model group(P<0.01). Change of renal tissue was improved in LBTG and HBTG compared with model group

level of BUN and Scr was significantly decreased in a dose-dependent manner(P<0.05

P<0.01)

the content of MDA was declined

but the activity of SOD was increased in serum and renal cortex homogenate(P<0.05). Conclusion: Breviscapine may reduce cisplatin-induced nephrotoxicity and its mechanism may be correlative with that breviscapine would inhibit blood and rencal cortex lipid peroxidation increasing