Design,Optimization and Quality Evaluation of Artemisinin Self-emulsifying Preparation
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Design,Optimization and Quality Evaluation of Artemisinin Self-emulsifying Preparation
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 9, Pages: 59-63(2012)
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Published:2012
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ZHANG Xiao-mei, WANG Yun-hong, YANG Rong-ping, et al. Design,Optimization and Quality Evaluation of Artemisinin Self-emulsifying Preparation[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 59-63.
DOI:
ZHANG Xiao-mei, WANG Yun-hong, YANG Rong-ping, et al. Design,Optimization and Quality Evaluation of Artemisinin Self-emulsifying Preparation[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 59-63.DOI:
Design,Optimization and Quality Evaluation of Artemisinin Self-emulsifying Preparation
Objective: To design and optimize technology of artemisinin self-emulsifying preparation
and evaluate its in vitro quality evaluation. Method: Excipients was selected by determining solubility of artemidinin in different oils
surfactants and co-surfactants. Based on ternary phase diagram
artemisinin self-emulsifying prescription was optimized by central composite design method.With appearance
solubility
emulsification time
particle size after emulsified and polydispersity coefficient as indexes to do quality evaluation of artemisinin emulsifying preparation. Result: Optimum prescription of this preparation was:MCT-tween-80-ethanol 31∶37∶20
it had uniform and transparent appearance
particle size was 234.7 nm
polydispersity coefficient 0.235
self-emulsifying time was 25 s
solubility was 2.775 g·L-1. Conclusion: Technology of arteannuin self-emulsifying preparation was simple and stable