Effect of Cilan Kangpi Oral Liquid on Postoperative Fatigue Syndrome Model in Rats

GUO Jian-sheng; LI Si-jia; LI Ruo-cun; NIE Zi-wen; ZHANG Meng; CHEN Jun; LIU Hong-yan

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Effect of Cilan Kangpi Oral Liquid on Postoperative Fatigue Syndrome Model in Rats

更新时间：2024-01-04

- Effect of Cilan Kangpi Oral Liquid on Postoperative Fatigue Syndrome Model in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 1, Pages: 158-161(2012)
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- Published：2012
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GUO Jian-sheng, LI Si-jia, LI Ruo-cun, et al. Effect of Cilan Kangpi Oral Liquid on Postoperative Fatigue Syndrome Model in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 158-161.
DOI：

GUO Jian-sheng, LI Si-jia, LI Ruo-cun, et al. Effect of Cilan Kangpi Oral Liquid on Postoperative Fatigue Syndrome Model in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 158-161. DOI：

摘要

目的 :观察刺蓝抗疲口服液对手术后疲劳综合征(POFS) 大鼠模型的作用及其机制。方法 :将60只SD大鼠随机分成空白组、假手术组、模型组、刺蓝抗疲口服液低、中、高剂量组(4.7

9.4

18.8 g ·kg-1 ·d-1)。采用切除大鼠部分肝脏的方法建立POFS大鼠模型

以肛温、体力活动、血常规、白蛋白、转铁蛋白等为指标

观察ig给药7 d刺蓝抗疲口服液对POFS大鼠的影响。结果 :刺蓝抗疲口服液中剂量组大鼠在悬挂实验中的抬头次数与抬头最高高度与模型组有显著差异(P<0.01)

术后大鼠肛温的恢复与模型组有差异(P<0.01);高剂量组大鼠白蛋白、转铁蛋白明显提高(P<0.05)。结论 :刺蓝抗疲口服液能缩短模型大鼠POFS 持续时间

减轻POFS 的程度。

Abstract

Objective :To observe the influence and the mechanism of Cilan Kangpi oral liquid on postoperative fatigue syndromes(POFS). Method :Sixty SD rats were randomly divided into six groups: normal control group

model group

sham operation group

low-dose Cilan Kangpi group(4.7 g ·kg-1)

middle-dose Cilan Kangpi group and high-dose Cilan Kangpi group.Using the resection of partial liver of rats to establish POFS model

anus temperature

physical activity

blood tests

albumin and transferrin were observed after Cilan Kangpi oral liquid was given for seven days. Result :Compared with model group

the frequency and height of rising head and in middle dose group in suspension experiment were obviously different (P<0.01)

the recovery of anus temperature was different (P<0.01)after surgery; albumin and transferrin of high doses of rats were obviously improved (P<0.05). Conclusion :Cilan Kangpi oral liquid can shorten the duration and reduce the degree of POFS in model rats.

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Related Institution

School of Traditional Chinese Medicine， Beijing University of Chinese Medicine

School of Nursing，Beijing University of Chinese Medicine

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