Objective : By analyzing the compatibility regularity of Chinese medicine in one thousand three hundred and seven prescriptions

to discuss the application regularity of the herbs with neutral nature. Method : One thousand three hundred and seven prescriptions were screened from Herbal Prescription Science and 〈Pharmacopoeia of the People’s Republic of China〉

and the herbal nature was determined according to the Pharmacopoeia

the data were inputted into the database software

Data Analysis System of Traditional Chinese Medicine Herbal Prescription to analyze the relationship between herbal nature and prescription

and the relationship between prescription and syndromes. The paired correlation analysis and two categories of non-conditional logistic regression analysis were carried on by SPSS 13.0 statistic software to analyze the relativity between compatibility of Chinese medicines with neutral nature and different syndromes. Result : The number of the Chinese medicines with neutral nature as a guide drug was 3.9 times more than the Chinese medicines with cold and heat nature. The Chinese medicines with neutral nature as a monarch drug and a minister drug were firstly used in deficiency syndrome

secondly used in blood stasis syndrome and phlegm-dampness syndrome. The total application frequencies of the Chinese medicines with neutral nature which were used in cold syndrome

heat syndrome

the syndrome without obvious cold and heat

and the syndrome of intermingled cold and heat

were 22%

18%

25%

and 18%

respectively; the frequencies in deficiency syndrome

excess syndrome

and the syndrome of intermingled deficiency and excess

were 27%

17%

25%

respectively; the frequencies in qi deficiency syndrome

blood deficiency syndrome

cold syndrome

syndrome without obvious cold and heat

and deficiency syndrome

were 1.5

1.4

1.6

1.2 times

respectively

more than the herbs with cold and heat nature. Conclusion : In terms of compatibility regularity

the Chinese medicines with neutral nature are most frequently used as guide drug;in terms of the diseases and syndromes

they are commonly used in deficiency syndrome

and the syndrome of intermingled deficiency and excess. The Chinese medicines with neutral nature are commonly used herbs in Qi deficiency syndrome

blood deficiency syndrome

cold syndrome

the syndrome without obvious cold and heat

and deficiency syndrome

and more appropriate for compatible application than the Chinese medicineswith cold and heat nature.