Meta-Analysis of Traditional Chinese Medicine Plus Chemotherapy in Treatment of Postoperative Gastric Cancer
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Meta-Analysis of Traditional Chinese Medicine Plus Chemotherapy in Treatment of Postoperative Gastric Cancer
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 1, Pages: 261-266(2012)
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Published:2012
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SHI Guo-jun, SHAN Guang-zhi, ZHOU Yi-qiang, et al. Meta-Analysis of Traditional Chinese Medicine Plus Chemotherapy in Treatment of Postoperative Gastric Cancer[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 261-266.
DOI:
SHI Guo-jun, SHAN Guang-zhi, ZHOU Yi-qiang, et al. Meta-Analysis of Traditional Chinese Medicine Plus Chemotherapy in Treatment of Postoperative Gastric Cancer[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 261-266.DOI:
Meta-Analysis of Traditional Chinese Medicine Plus Chemotherapy in Treatment of Postoperative Gastric Cancer
To evaluate the efficacy and safety of traditional Chinese medicine(TCM)in treating postoperative gastric cancer. We searched CNKI
VIP
WanFang (2001 to 2010) for randomized control trials about traditional Chinese medicine plus chemotherapy in the treatment of postoperative gastric cancer.Trial screening
quality assessment of included trials
and data extract were conducted. Statistical analysis was conductedby using RevMan 5.0 software. A total of 21 randomized controlled trials were included
meta analysis showed
① KPS score has 10 RCTs. 5 RCTs of classification variables no heterogeneity
KPS score 2.35
95%CI(1.78
3.10)
P<0.01]
5 RCTs of continuous variables no heterogeneity
KPS score
the differences are significant. ② Immune function 5 RCTs have heterogeneity and use random effects model.CD3 CD4
CD4/CD8 . The differences are significant. ③ Survival 3 RCTs have no heterogeneity
and use fixed effects model. One year survival rate is
2 year survival rate
3 year survival rate . The differences are significant. ④ Gastrointestinal reaction 5 RCTs have no heterogeneity
and use fixed effects model. Bad appetite above Ⅱ degrees is
Nausea and vomiting above Ⅱ degrees are . The differences are significant. ⑤ Blood toxicity 7 RCTs have no heterogeneity
and use fixed effects model. Leucopenia reduce above Ⅱ degrees
HB reduce above Ⅱ degrees
PLT reduce above Ⅱ degrees . The differences are significant. Traditional Chinese medicine plus chemotherapy is effective in curing postoperative gastric cancer. It can improve KPS score
immune function and survival rate
and reduce gastrointestinal reaction and blood toxicity.But the quality of studies is low
more large-scale multi-center randomized trials are needed.