Objective: To study effect of Qingkai Xiaoyanfang and its components on rhinitis chronic in rat. Method: Two groups of SD rats were randomly divided into control group and rhinitis chronic model group

with 10 rats in control group and 70 in model group. NO2 or SO2 being as irritants rats were stimulated for 26 days

and injected estradiol benzoate(EB) im for 7 days to establish rhinitis chronic models. Then the 70 rats were divided into model group

Biyankang tablet group(410 mg ·kg-1)

Huodanwan group(2 000 mg ·kg-1)

Qingkai Xiaoyanfang group(46.6 mg ·kg-1)

patchouli oil group(13.3 mg ·kg-1)and pig deoxycholic acid group(33.3 mg ·kg-1). The experiment lasted 30 days. The ethological performance of nasal symptoms

total IgE in blood serum

eosinophil(EOS) in nasal secretions and blood serum

the nose mucosa by light microscope were observed. Result: The model rats’ nasal symptoms score and secretions EOS count were increased

the nasal mucosa was thinned

and showed highly significant compared with the normal group (P<0.01 or P<0.05). After 4 weeks

Qingkai Xiaoyanfang and its components could obviously improve the symptoms induced by SO2

as the ethological performance of rats (2.10±0.32)

EOS in nasal secretions (11.8±4.52) cells and blood serum

the thickness of nose mucosa(0.239±0.04)mm (P<0.01 or P<0.05). NO2 model group could effectively relieve nasal symptoms

reduced the nasal EOS infiltration (P<0.01 or P<0.05)

and ameliorated other relevant symptoms. Of which the ethological performance score of Qingkai Xiaoyanfang decreased to (5.80±2.35)

nasal EOS secretions declined to (35.6±8.07) cells and

the nasal mucosa thickness averaged (0.290±0.04) mm. Some corresponding symptoms were alleviated by the recipe. Its components could obviously improve the nasal symptoms and reduced nasal secretions EOS in rhinitis chronic rat models (P<0.01 or P<0.05). The results were statistically significant. Conclusion: Qingkai Xiaoyanfang which has better effects than its components on nasal secretions EOS and nasal mucosa thickness could relieve the symptoms on rhinitis chronic. It has potential therapeutic effects on rhinitis chronic.