Preparation and  Release of Clinopodii Saponin Microspheres

CHEN Jiao-ting; SUN Xiang-ting; ZHANG Dao-ying; ZENG Jing

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Preparation and Release of Clinopodii Saponin Microspheres

更新时间：2024-01-04

- Preparation and Release of Clinopodii Saponin Microspheres
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 2, Pages: 15-17(2012)
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- Published：2012
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CHEN Jiao-ting, SUN Xiang-ting, ZHANG Dao-ying, et al. Preparation and Release of Clinopodii Saponin Microspheres[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(2): 15-17.
DOI：

CHEN Jiao-ting, SUN Xiang-ting, ZHANG Dao-ying, et al. Preparation and Release of Clinopodii Saponin Microspheres[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(2): 15-17. DOI：

摘要

目的: 以丙烯酸树脂Ⅱ为囊材制备断血流皂苷微球及评价其体外释药情况。方法: 用喷雾干燥法制备断血流皂苷微球

以微球的外观形态、收率及包封率为优化指标

用正交试验设计优化制备条件

并对微球进行2种不同介质(人工胃液、人工肠液)中的体外释放度评价。结果: 制得的断血流皂苷微球在电镜下

球形表面圆整

粒径分布适宜

收率(97.53±2.39)%

包封率(92.87±4.2)%。断血流皂苷微球在人工胃液中3 h不释药;在人工肠液中1 h内释放不到30%

3 h释药接近60%;此后释药趋于缓慢

8 h释药>80%。结论: 所制备断血流皂苷微球有良好的外观形态、较高的收率及包封率。

Abstract

Objective: To prepare clinopodii saponin microspheres with acrylic acid resin Ⅱas material and evaluate its release in vitro. Method: Clinopodii saponin microspheres were prepared by spray drying technique.Preparation technology was optimized by orthogonal test design with appearances

yield and entrapment efficiency as indexes.In vitro drug release of microspheres were carried out in two different media of artificial gastric juice and artificial intestinal fluid. Result: Clinopodii saponin microspheres showed good spherical geometry

smooth surface and suitable size distribution under scanning electron micrographs.Yield was(97.53±2.39)%

entrapment efficiency was (92.87±4.2)%.Little release of clinopodii saponin microspheres were observed in artificial gastric juice.In artificial intestinal fluid

release of clinopodii saponin was less than 30% in 1 h

close to 60% in 3 h

then release slowly

more than 80% in 8 h. Conclusion: Prepared clinopodii saponin microspheres had good appearances

high yield and high entrapment efficiency.

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Related Author

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Jing-lan WU

Yong-ping ZHANG

Jian XU

Di WEN

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ZHANG Yu-yan

LI Jin-hui

Related Institution

Guizhou University of Traditional Chinese Medicine

College of Life Science and Engineering,Lanzhou University of Technology

Department of Pharmacology,School of Basic Medicine,Capital Medical University

Hebei Province Key Laboratory of Research and Development for Chinese Medicine, Chengde Medical College

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