Objective: To study the cardioprotective effect of 17-methoxyl-7-hydroxyl-benzofuran chalcone (YLSC) in rats with myocardial injury induced by pituitrin. Method: Seventy SD rats were randomly divided into seven groups: normal group

vehicle group

model control group

positive control group and YLSC groups(1.25

2.50

5.00 mg ·kg-1). Pituitrin(0.75 U ·kg-1) was injected through sublingual vein to erect model of acute myocardium ischemia. The changes of ST segment on the Ⅱroad electrocardiogram and contents of creatine kinase-MB(CK-MB)

Troponin (cTnI)

myoglobin(MyoG) in serum were observed and compared. Meanwhile

myocardium pathological structures were accessed with HE staining. Myocardial ischemia sizes were measured by Evans blue and TTC staining when the experiment was over. Result: Compared with the model control group

YLSC could significantly decrease the height of ST segment at 15 s

30 s

1 min and 5 min in a dose-dependent manner(P<0.05 or P<0.01). It also could reduce myocardial ischemia sizes and contents of CK-MB

cTnI

MyoG in serum(P<0.05 or P<0.01). Furthermore

these damages induced by pituitrin including myocardium edema

hemorrhage and exudation of inflammatory cells were improved in YLSC treated groups. Conclusion: YLSC has obvious protective effects against pituitrin induced myocardial injury in rats.