Influenction of Shuwei Decoction on Substance P and Interstitial Cells of Cajal in Functional Dyspepsia Rat

XU Yin; GUO Xuan; MI Yan-hong; WANG Xiao-juan; TANG Song-yun; LIU Hong; ZHANG Xin; RAO Wen-juan; LI Yong-jing

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Influenction of Shuwei Decoction on Substance P and Interstitial Cells of Cajal in Functional Dyspepsia Rat

更新时间：2024-01-04

- Influenction of Shuwei Decoction on Substance P and Interstitial Cells of Cajal in Functional Dyspepsia Rat
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 6, Pages: 206-209(2012)
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- Published：2012
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XU Yin, GUO Xuan, MI Yan-hong, et al. Influenction of Shuwei Decoction on Substance P and Interstitial Cells of Cajal in Functional Dyspepsia Rat[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(6): 206-209.
DOI：

XU Yin, GUO Xuan, MI Yan-hong, et al. Influenction of Shuwei Decoction on Substance P and Interstitial Cells of Cajal in Functional Dyspepsia Rat[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(6): 206-209. DOI：

摘要

目的: 观察舒胃汤对肝郁脾虚型功能性消化不良(functional dyspepsia

FD)大鼠胃排空、P物质(substance P

SP)和胃窦Cajal间质细胞的影响

探讨舒胃汤治疗FD的机制。方法: 60只SPF级SD大鼠分为6组

分别为舒胃汤低剂量组(舒低组)、舒胃汤高剂量组(舒高组)、中成药组(木香顺气丸组)、莫沙必利组、空白对照组、模型对照组

每组10只;舒低组、舒高组分别给予舒胃汤7.67 g·kg-1

30.68 g·kg-1

木香顺气丸组予木香顺气丸1.65 g·kg-1、莫沙必利组予莫沙必利1.37 mg·kg-1

采用夹尾刺激方法制造功能性消化不良造模7 d

造模后第3 d各组给予相应药液ig

对照组和模型组每日予以蒸馏水(10 mL·kg-1)ig

均为每日1次

持续14 d。检测大鼠胃排空、用放射免疫法检测血浆SP水平、透射电镜下观察Cajal间质细胞的结构变化。结果: 大鼠模型组胃排空(48.12±10.17)%与空白组(89.00±7.59)%比较延迟(P<0.05)

血浆SP模型组(5.32±2.12)ng·L-1与空白组(19.56±5.01)ng·L-1比较

显著降低(P<0.05)。大鼠胃排空中成药组(58.35±8.71)%、莫沙必利组(78.17±10.74)%、舒低组(60.39±3.48)%、舒高组(76.80±6.96)%与模型组(48.12±10.17)%比较改善(均P<0.05);血浆SP含量中成药组(12.89±2.10)ng·L-1、莫沙必利组(17.86±3.56)ng·L-1、舒低组(8.03±2.51)ng·L-1、舒高组(13.79±2.58)ng·L-1与模型组(5.32±2.12)ng·L-1比较明显增加(均P<0.05)

胃窦部Cajal间质细胞结构改善。结论: 功能性消化不良大鼠胃肠运动抑制

舒胃汤能够提高SP水平

改善胃窦ICC细胞结构功能

促进胃排空

恢复胃肠道运动功能。

Abstract

Objective: To observe the effects and mechanism of Shuwei decotion on the gastric emptying

substance P (SP) and gastric antrum of interstitial cells of Cajal (ICC) in functional dyspepsia (FD) with stagnation of liver-Qi and deficiency of the spleen. Method: The sixty SD rats were randomly divided into 6 groups: Shuwei decoction low dose group

Shuwei decoction high dose group

Muxiang Shunqi pill group

mosapride group

control group and model group

with 10 rats in each group. Shuwei decoction groups were administrated with Shuwei decoction at doses of 7.67 g·kg-1

30.68 g·kg-1

and muxiangshunqi pill group was given Muxiang Shunqi pill of 1.65 g·kg-1

and mosapride group was given mosapride of 1.37 mg·kg-1. The rats FD model ws maded by clasping their tails except the control group.After 3 days

the control and model groups were given distilled water ig(10 mL·kg-1); the normal group and model group were given physiological saline intragastrically; the treated rats were given corresponding drugs for 14 days. To observe gastric emptying

the content of SP were determined by radiommunoassay

structure change of interstitial cells of cajal in gastric antrum was observed by transmission electron microscope. Result: The gastric emptying was delayed and the content of SP obviously decreased(P<0.05) in model group. compared with model group

Muxiang Shunqi pill group (58.35±8.71)%

mosapride group(78.17±10.74)%

Shuwei decoction low dose group(60.39±3.48)% and Shuwei decoction high dose group(76.80±6.96)% improved gastric emptying(P<0.05); compared with SP level(5.32±2.12)ng·L-1 of model group

Muxiang Shunqi pill group(12.89±2.10) ng·L-1

mosapride group(17.86±3.56) ng·L-1

Shuwei decoction low dose group(8.03±2.51) ng·L-1 and Shuwei decoction high dose group(13.79±2.58)ng·L-1 was significantly increased the plasma SP level (P<0.05). The structure change of ICC in gastric antrum improved after treatment. Conclusion: The gastrointestinal motility in FD rats was inhibited

Shuwei decoction can regulate the level of SP

improve the structure and function of ICC in gastric antrum

promote the gastric emptying and recovery the function of gastrointestinal motility.

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