Anti-inflammation and Pharmacodynamics of Leigongteng Duogan Tablet

ZHANG Qiu-ping; TIAN Zhen; LIU Zhi-hong; SONG Hong-tao

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Anti-inflammation and Pharmacodynamics of Leigongteng Duogan Tablet

更新时间：2024-01-04

- Anti-inflammation and Pharmacodynamics of Leigongteng Duogan Tablet
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 6, Pages: 122-124(2012)
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- Published：2012
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ZHANG Qiu-ping, TIAN Zhen, LIU Zhi-hong, et al. Anti-inflammation and Pharmacodynamics of Leigongteng Duogan Tablet[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(6): 122-124.
DOI：

ZHANG Qiu-ping, TIAN Zhen, LIU Zhi-hong, et al. Anti-inflammation and Pharmacodynamics of Leigongteng Duogan Tablet[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(6): 122-124. DOI：

摘要

目的: 采用药理效应法探讨雷公藤多苷片的药效动力学参数。方法: 将8组雄性Wistar大鼠

皮内注射0.1 mL完全弗氏佐剂(CFA)第14天后

制得佐剂性关节炎模型。然后

分别以白细胞介素-1(IL-1)和肿瘤坏死因子-α(TNF-α)含量变化率为效应指标测定雷公藤多苷片的药效动力学参数。结果: 雷公藤多苷片大鼠ig给药后

以IL-1 和 TNF-α变化率为指标

时间体存量均符合二室开放模型

主要药代动力学参数分别为t1/2α 0.230和0.196 h

t1/2β0.283和0.246 h

V1/F 2.174

1.798 L·kg-1

AUC0-∞ 1.236

1.578 mg·L-1·h-1。结论: 雷公藤多苷片在大鼠体内药动学行为符合线性二室模型

在体内的分布和消除均较快。

Abstract

Objective: To study the anti-inflammation and pharmacodynamics of Leigongteng Duogan Pian. Method: The model of adjuvant arthritis in mice was established with complete freund’s adjuvant(CFA) and the changes of interleukin-1(IL-1) and tumor necrosis factor-α(TNF-α) were determined to estimate the pharmacodynamics. Result: The results showed that concentration-time curves after iv leigongteng duogan tablet were fit to a two-compartment model

The t1/2α was 0.230

0.196 h

t1/2βwas 0.283

0.246 h

V1/F was 2.174

1.798 L·kg-1

AUC0-∞was 1.236

1.578 mg·L-1·h-1. Conclusion: Pharmacodynamics of anti-inflammation conforms to linear two-compartment model and the distribution and elimination are both fast in mouses in vivo.

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Related Institution

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