Preparation and Stability of Tanshinone Freeze-dried Emulsion

WANG Xiu-li; WANG Hua-qiang; LIAO Yan; WANG Wen-ping; GAO Wei

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Preparation and Stability of Tanshinone Freeze-dried Emulsion

更新时间：2024-01-04

- Preparation and Stability of Tanshinone Freeze-dried Emulsion
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 7, Pages: 54-57(2012)
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- Published：2012
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WANG Xiu-li, WANG Hua-qiang, LIAO Yan, et al. Preparation and Stability of Tanshinone Freeze-dried Emulsion[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(7): 54-57.
DOI：

WANG Xiu-li, WANG Hua-qiang, LIAO Yan, et al. Preparation and Stability of Tanshinone Freeze-dried Emulsion[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(7): 54-57. DOI：

摘要

目的: 比较丹参酮乳剂和丹参酮冻干乳剂的稳定性。方法: 通过长期留样试验和影响因素试验

对丹参酮乳剂和丹参酮冻干乳剂的外观、丹参酮IIA的含量以及冻干乳剂的复溶情况进行了考察。结果: 丹参酮乳剂在25 ℃长期留样试验和热循环试验中

系统稳定性明显降低;在4

25 ℃的长期留样试验和高温、强光试验中

丹参酮IIA含量均不同程度降低。丹参酮冻干乳剂在所有长期留样试验和影响因素试验中

均表现出良好的系统稳定性;在25 ℃的长期留样试验和高温、强光试验中

丹参酮IIA含量均不同程度降低

但降低程度明显低于同等条件下的丹参酮乳剂。结论: 在提高乳剂系统和丹参酮IIA成分的稳定性2方面

丹参酮冻干乳剂均明显优于丹参酮乳剂。

Abstract

Objective: Comparative study on stability of tanshinone emulsion and tanshinone freeze-dried emulsion. Method: Appearance of tanshinone emulsion and tanshinone freeze-dried emulsion and the content of tanshinone and reconstitution of freeze-dried emulsion were investigated by influential factors test and long-term sample test. Result: System stability of tanshinone emulsion had significantly reduced in 25 ℃ long-term sample test and thermal cycling test;The content of tanshinoneIIA was reduced to varying degrees in 4

25 ℃ long-term sample test and high temperature and light test.System stability of tanshinone freeze-dried emulsion showed good in long-term sample test and influential factors test;The content of tanshinoneIIA was reduced to varying degrees in 25 ℃ long-term sample test and high temperature and light test

but reduced degree was lower than that of tanshinone emulsion in tha same conditions. Conclusion: Tanshinone freeze-dried emulsion showed significantly better than tanshinone emulsion in improving stability of emulsion system and tanshinoneIIA.

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