Objective: To study the antidepressant effect of Jiaotai pill with different proportions. Method: Male Kunming mice were randomly divided into control group

fluoxetine (7.5 mg·kg-1) group and five different proportions of Jiaotai pill in high and low dose groups (Rhizoma Coptidis Granules: Cinnamon Granules 10: 1

1: 10

10: 0

0: 10

1: 1) according to body weight

togather 12 groups. The tail suspension test (TST) and the forced swimming test (FST) were used to observe the antidepressant effect of Jiaotai pillswith different proportions at 1 h after the administration (ig). Result: Compared with the control group

five different proportions of Jiaotai pill and fluoxetine (7.5 mg·kg-1) reduced the immobility time both in the TST and FST

more obviously in Jiaotai pill (Rhizoma Coptidis Granules: Cinnamon Granules 10: 1 and 1: 10). In the TST

the immobility time of Jiaotai pill (Rhizoma Coptidis Granules: Cinnamon Granules 10: 1) in high and low dose groups was (69.8 ± 18.1) s and (79.2± 14.6) s

respectively; the immobility time of Jiaotai pill (Rhizoma Coptidis Granules: Cinnamon Granules 1: 10) in high and low dose groups was (69.5 ± 21.7) s and (64.1 ± 26.0) s

respectively. In the FST

the immobility time of Jiaotai pill (Rhizoma Coptidis Granules: Cinnamon Granules 10: 1) in high and low dose groups was (83.6 ± 29.0) s and (72.9± 37.7) s

respectively; the immobility time of Jiaotai pill (Rhizoma Coptidis Granules: Cinnamon Granules 1: 10) in high and low dose groups was (92.2 ± 37.8) s and (71.9± 35.9) s

respectively. Compared with the control group

Jiaotai pill (Rhizoma Coptidis Granules: Cinnamon Granules 10: 1 and 1: 10) show an obvious difference in TST and FST test(P<0.05 or P<0.01). The same results in the TST werefound in the FST (P <0.01). Conclusion: The results suggested that different proportions of Jiaotai pill performed antidepressant effect

while there may be a difference in intensity of the effect.