Study on Wendan Granule in Treatment of Gastrointestinal Adverse Caused by Antiretroviral Therapy

ZHANG Xiao-wei; GUO Hui-jun; JIANG Feng; CHEN Xiu-min

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Study on Wendan Granule in Treatment of Gastrointestinal Adverse Caused by Antiretroviral Therapy

更新时间：2024-01-04

- Study on Wendan Granule in Treatment of Gastrointestinal Adverse Caused by Antiretroviral Therapy
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 7, Pages: 252-254(2012)
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- Published：2012
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ZHANG Xiao-wei, GUO Hui-jun, JIANG Feng, et al. Study on Wendan Granule in Treatment of Gastrointestinal Adverse Caused by Antiretroviral Therapy[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(7): 252-254.
DOI：

ZHANG Xiao-wei, GUO Hui-jun, JIANG Feng, et al. Study on Wendan Granule in Treatment of Gastrointestinal Adverse Caused by Antiretroviral Therapy[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(7): 252-254. DOI：

摘要

目的: 观察温胆颗粒对高效抗逆转录病毒疗法(HAART)致消化道不良反应发病率及临床症状影响情况。方法: 100例患者随机分两组

治疗组予温胆颗粒(15 g/次

2 次/d)

对照组予安慰剂(剂量为温胆颗粒的1/20)

1月后观察发病率情况

对发生症状者记录症状积分情况。结果: 温胆颗粒组消化道不良反应发病率为20.4%

对照组为48%

温胆颗粒组、对照组出现消化道不良反应患者症状总积分组间比较差异有统计学差异(P<0.05)

治疗前后症状总积分组内比较差异有统计学差异(P<0.05)。结论: 温胆颗粒可以降低HAART致消化道不良反应症状的发生。对于发生轻、中度消化道不良反应的患者中药治疗可以明显减轻临床症状。

Abstract

Objective: To observe effects of Wendan granulein the treatment of gastrointestinal adverse caused by highly active antiretroviral therapy(HAART). Method: One-hundred patients were divided into two groups randomly

treatment group was treated by wendan granule

control group was treated by placebo to observe the incidence of the gastrointestinal adverse and record the symptom score. Result: The incidence of gastrointestinal adverse caused by HAART in treatment group was 20.4%

while the placebo group was 48%. The symptoms score of gastrointestinal adverse between two groups showed a significant difference (P<0.05)

and the score before and after treatment in two groups was different (P<0.05). Conclusion: The wendan granule can reduce the incidence of gastrointestinal adverse caused by HAART. The treatment of Chinese medicine can significantly reduce the clinical symptoms

especially the mild or moderate symptoms.

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