Preparation and Anti-tumor Effect of Baicalin Liposome

HONG Yi; He Wei; LI Dan; HE Li; ZHANG Wei

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Preparation and Anti-tumor Effect of Baicalin Liposome

更新时间：2024-01-04

- Preparation and Anti-tumor Effect of Baicalin Liposome
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 3, Pages: 29-31(2012)
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- Published：2012
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HONG Yi, He Wei, LI Dan, et al. Preparation and Anti-tumor Effect of Baicalin Liposome[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(3): 29-31.
DOI：

HONG Yi, He Wei, LI Dan, et al. Preparation and Anti-tumor Effect of Baicalin Liposome[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(3): 29-31. DOI：

摘要

目的: 制备黄芩苷脂质体

考察其在体外对肝癌HepG2凋亡的影响。方法: 以包封率为主要指标

对制备方法、处方组成进行了考察

筛选最佳处方工艺

考察脂质体的形态、稳定性等理化性质

并考察对肝癌HepG2凋亡的影响。结果: 脂质体在电镜下呈类圆形

在冷藏条件下较稳定

采用薄膜分散法制备包封率为(34.62±0.89)%。细胞凋亡率与制剂的剂量和作用时间呈正相关。结论: 薄膜分散法制备黄芩苷脂质体简便易行

该制剂对HepG2细胞有明显的体外抑制作用。

Abstract

Objective: To prepare baicalin liposome and investigate effect of in vitro apoptosis on liver cancer HepG2. Method: With encapsulation efficiency as main index

investigated preparation method and prescription form

optimum prescription technology were selected

studied form

stability and other physical and chemical properties

and effect of apoptosis on liver cancer HepG2 were investigated. Result: Liposome was oval under electron microscope

it was stable under refrigerated conditions

prepared by film encapsulation efficiency was (34.62 ± 0.89)%. Cell apoptosis rate was positive correlation with dosage and action time of preparation. Conclusion: This method was simple and feasible. This preparation had significantly in vitro inhibition on HepG2 cell.

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Related Institution

Research Center for Differentiation and Development of Traditional Chinese Medicine （TCM） Basic Theory， Jiangxi Province Key Laboratory of TCM Etiopathogenisis， Jiangxi University of Chinese Medicine

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State Key Laboratory of Functions and Applications of Medicinal Plants，School of Pharmaceutical Sciences，Engineering Center of Microbiology and Biochemical Pharmacy，Experimental Animal Center，Guizhou Medical University

Chengdu University of Traditional Chinese Medicine

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