Preparation and Bioavailability of Ursolic Acid Self-Microemulsion

OU Xiao-xia; WANG Zheng-ming; FENG Liang

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Preparation and Bioavailability of Ursolic Acid Self-Microemulsion

更新时间：2024-01-04

- Preparation and Bioavailability of Ursolic Acid Self-Microemulsion
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 1, Pages: 36-39(2012)
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- Published：2012
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OU Xiao-xia, WANG Zheng-ming, FENG Liang. Preparation and Bioavailability of Ursolic Acid Self-Microemulsion[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 36-39.
DOI：

OU Xiao-xia, WANG Zheng-ming, FENG Liang. Preparation and Bioavailability of Ursolic Acid Self-Microemulsion[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 36-39. DOI：

摘要

目的: 制备熊果酸自微乳给药体系

建立HPLC-MS方法研究熊果酸自微乳的生物利用度和药物动力学。方法: 以OP乳化剂、吐温-20、异丙醇和油酸制备熊果酸自微乳给药系统

并考察其稳定性、粒径和Zeta电位。通过口服给药

研究其体内的生物利用度和药物动力学。结果: 所制备的熊果酸自微乳在1个月内稳定

平均粒径32.74 nm

Zeta电位4.21 mV。自微乳的相对生物利用度326.5%;缓释片的相对生物利用度256.6%;相对与缓释片

自微乳的相对生物利用度为127.2%。结论: 所制备的自微乳给药系统能提高熊果酸的生物利用度。

Abstract

Objective: To prepare delivery system of ursolic acid self-microemulsion

and establish bioavailability and pharmacokinetics of ursolic acid self-microemulsion by HPLC-MS. Method: Ursolic acid self-microemulsion delivery system was prepared with OP emulsifier

Tween-20

isopropyl alcohol and oleic acid

and investigated its stability

particle size and Zeta potential.In vivo bioavailability and pharmacokinetics in rats were evaluated by oral administration. Result: Ursolic acid self-microemulsion was stable within a month

average particle size and Zeta potential were 32.74 nm and 4.21 mV

respectively.Relative bioavailability of ursolic acid self-microemulsion and sustained-release tablets were 326.5% and 256.6%

respectively; and then relative bioavailability of microemulsion delivery system was 127.2% to sustained-release tablets. Conclusion: This prepared self-microemulsion delivery system could enhance bioavailability of ursolic acid.

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