Objective : To investigate pharmacokinetics of panax notoginseng saponins (PNS) enteric pellets in Beagle dogs and study correlation between in vivo absorption and in vitro release of PNS enteric pellets. Method : Two-cycle crossover test design was used

six Beagle dogs oralled self-made PNS ordinary capsules or self-made PNS enteric pellets(capsule mode)

and determined plasma concentration by HPLC

calculated pharmacokinetic parameters.Then compared bioavailability

adopted linear regression of in vitro cumulative release percentage and in vivo cumulative absorption. Result: Bioavailability of Notoginsenoside R1

Ginsenoside Rb1and Ginsenoside Rg1 in PNS enteric pellets were 520.56%

367.70% and 251.66% respectively. Their mean residence time was longer than referenced preparation in vivo. Correlation coefficient of R1

Rb1 and Rg1 were 0.784 9

0.877 2 and 0.691 2 respectively. Conclusion : Bioavailability of PNS enteric pellets was higher than PNS capsule. There was a bad correlation of R1

Rb1 and Rg1 between in vivo absorption and in vitro release in pH 6.8 buffer liquid.