Advances in the Intestinal Bacteria Metabolic of Chemical Compositions from Chinese Medicine

XIAO Juan; WANG Ying; WANG Xin-hong; AN Rui

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Advances in the Intestinal Bacteria Metabolic of Chemical Compositions from Chinese Medicine

更新时间：2024-01-04

- Advances in the Intestinal Bacteria Metabolic of Chemical Compositions from Chinese Medicine
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 5, Pages: 247-251(2012)
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- Published：2012
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XIAO Juan, WANG Ying, WANG Xin-hong, et al. Advances in the Intestinal Bacteria Metabolic of Chemical Compositions from Chinese Medicine[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(5): 247-251.
DOI：

XIAO Juan, WANG Ying, WANG Xin-hong, et al. Advances in the Intestinal Bacteria Metabolic of Chemical Compositions from Chinese Medicine[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(5): 247-251. DOI：

摘要

介绍肠道代谢研究方法及肠道菌群对中药成分的代谢作用

为开展中药代谢研究提供参考。查阅近年国内外有关中药成分肠菌代谢研究方面的相关文献40篇

并对其进行归纳

分析和总结。结果显示目前对肠菌代谢研究主要有4个方面

且对黄酮类

皂苷类

生物碱类

蒽醌类

单萜类等中药成分的肠菌代谢研究最多。肠道菌群对中药成分的生物转化以水解为主

不少苷类成分肠菌代谢为苷元后更易吸收发挥药效。肠道药物代谢研究对临床中西药物合用上有指导意义。中药化学成分肠菌代谢研究有助于了解药物作用机制及作用物质基础

加快中药现代化研究进程。

Abstract

To review the intestinal tract metabolism research methods and intestinal flora metabolism of Chinese medicine

its gives the reference for the Chinese medicine metabolism research. Literatures in recent years about the intestinal bacteria metabolic of Chinese medicine compositions have been summarized and analyzed. Currently

there are four aspects for intestinal bacteria metabolism research

and more studies on five types of Chinese medicines-flavonoids

saponins

alkaloids

anthraquinones and monoterpenes are developed. Chinese medicines were mainly biotransformated by intestinal micro-flora with hydrolysis

most glycosides were translated into aglycones which were easily be absorbed and utilized. Researches on intestinal drug metabolism have a guiding significance in combined Chinese and Western medicines used in clinical.Intestinal bacterial metabolism of Chinese medicine compositions researches help us to understand the mechanism of drug action

and promote the modernization of traditional Chinese medicine.

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Related Author

ZHANG Haibo

CHEN Yadong

CHANG Xuesong

LIU Yihong

LEI Chenjing

MA Changju

DING Lina

YU Yaya

Related Institution

The Second Affiliated Hospital of Guangzhou University of Chinese Medicine （Guangdong Provincial Hospital of Chinese Medicine）

Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome

HongKong-Macao Joint Lab on Chinese Medicine and Immune Disease Research

The Second Clinical College of Guangzhou University of Chinese Medicine

Youjiang Medical University for Nationalities

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