Preparation and Evaluation its  Release of Fibrauretinum Colon Targeting Tablets

LIANG Mei-yi; HUANG Yun-ran; ZHOU Yi-sheng; YI Jing-li; ZHANG Jia-jia

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Preparation and Evaluation its Release of Fibrauretinum Colon Targeting Tablets

更新时间：2024-01-04

- Preparation and Evaluation its Release of Fibrauretinum Colon Targeting Tablets
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 6, Pages: 38-41(2012)
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- Published：2012
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LIANG Mei-yi, HUANG Yun-ran, ZHOU Yi-sheng, et al. Preparation and Evaluation its Release of Fibrauretinum Colon Targeting Tablets[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(6): 38-41.
DOI：

LIANG Mei-yi, HUANG Yun-ran, ZHOU Yi-sheng, et al. Preparation and Evaluation its Release of Fibrauretinum Colon Targeting Tablets[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(6): 38-41. DOI：

摘要

目的: 制备pH依赖、时滞双重机制控制的黄藤素结肠定位片释药系统

并考察其体外释放度。方法: 以羟丙甲基纤维素和聚乙二醇6 000作为隔离层

以丙烯酸树脂Ⅳ号和聚乙烯吡咯烷酮作为时滞层

以pH依赖型丙烯酸树脂Ⅱ和丙烯酸树脂Ⅲ的混合溶液作为外层肠溶层。考察包衣片在体外模拟人体胃肠道环境中的释药情况。结果: 制备的黄藤素结肠定位片在pH 1.0人工胃液中2 h不释药;在pH 6.8人工小肠液中3.5 h释药量<1%;在人工结肠液中6 h基本释药完全。结论: 所制备的黄藤素结肠定位片具有良好的结肠定位效果。

Abstract

Objective: To prepare fibrauretinum colon targeting tablets delivery system controlled by pH-dependent and time-dependent effects

and to investigate its in vitro release. Method: Fibrauretinum colon targeting tablets were coated sequentially with isolated layer of HPMC and PEG 6 000

time-dependent layer of polyacrylic resin Ⅳ and PVP

and outermost enteric coating layer of polyacrylic resin Ⅱand polyacrylic resin Ⅲ. Release situation of coated tablets in artificial gastrointestinal environment were investigated. Result: There was no drug release of prepared fibrauretinum colon targeting tablets in pH 1.0 artificial gastric juice in 2 hours;In pH 6.8 artificial intesrinal fluid

the amount of release was less than 1% in 3.5 hours;But in pH 7.6 artificial colon fluid

drug was completely released within 6 hours. Conclusion: This study reveals that fibrauretinum colon targeting tablets had a good effect of colon targeting.

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