Progress of Study on Chemical Stability of Polysorbate 80
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Progress of Study on Chemical Stability of Polysorbate 80
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 1, Pages: 251-254(2012)
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Published:2012
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TAN Zhi-gao, CHAO Zhi-mao, LIU Hai-ping, et al. Progress of Study on Chemical Stability of Polysorbate 80[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 251-254.
DOI:
TAN Zhi-gao, CHAO Zhi-mao, LIU Hai-ping, et al. Progress of Study on Chemical Stability of Polysorbate 80[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 251-254.DOI:
Progress of Study on Chemical Stability of Polysorbate 80
To carry out the literature arrangement and analysis about chemical instability of Tween-80 (polysorbate 80) and its compatibility and preparation. We took Tween-80 as a keyword
indexed systematically some databases of PubMed
Wiley Online Library
Science
ScienceDirect
Highwire
Biomed Central
and CNKI up to now
picked up 35 related references
and summarized according to the kinds of organic reaction. The organic reactions
giving expression to the unstable property of Tween-80
included hydrolysis
complexation
autoxidation
polymerization
photodegeneration
and an undefined reaction. When the injection containing Tween-80 is researched and developed
the probalble interaction of Tween-80 and medicinal molecule and the procedure and condition of all links from raw material choice to clinical usage should be considered thoroughly. We should prevent the appearance of any unstable phenomena and prepare safe and stable injection preparation containing Tween-80.
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