Objective :Taguchi experimental design method was used to optimize of microwave extraction process for Rukuaixiao oral liquid. Method :L9 (34) orthogonal test was used to optimize extraction process of medicine from Rukuaixiao oral liquid with active ingredient in orange (hesperidin) as index. Investigation factors included extraction power

extraction time

the amount of solvent. Result :The best microwave extraction technology was as follows: microwave extraction power was 6 000 W

extracted 45 minutes with 6 times the amount of water

compared with traditional boiled extraction

extract ratio of hesperidin increased 80%

and extraction time was shorten

the amount of water was only 27.3% to original technology. Conclusion :Optimum technology saved energy and time of medicine extraction and concentration process.