Percutaneous Penetration of Main Active Ingredient from Fufang Kali Ziran Gel

XING Jian-guo; WANG Xin-chun; ZHAO Yuan; MA Jian-hong; XUE Gui-peng; LIU Gui-hua

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Percutaneous Penetration of Main Active Ingredient from Fufang Kali Ziran Gel

更新时间：2024-01-04

- Percutaneous Penetration of Main Active Ingredient from Fufang Kali Ziran Gel
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 3, Pages: 19-22(2012)
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- Published：2012
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XING Jian-guo, WANG Xin-chun, ZHAO Yuan, et al. Percutaneous Penetration of Main Active Ingredient from Fufang Kali Ziran Gel[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(3): 19-22.
DOI：

XING Jian-guo, WANG Xin-chun, ZHAO Yuan, et al. Percutaneous Penetration of Main Active Ingredient from Fufang Kali Ziran Gel[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(3): 19-22. DOI：

摘要

目的: 研究不同透皮促进剂对复方卡力孜然凝胶剂3种有效成分体外经皮渗透的影响

筛选有效的透皮吸收促进剂。方法: 采用改良 Franz 扩散池法、离体鼠皮进行体外透皮试验

HPLC测定透皮吸收促进剂对3种有效成分补骨脂素、异补骨脂素及蛇床子素的累积透过量及透皮速率的影响。结果: 不同促透剂对复方卡力孜然凝胶剂中补骨脂素、异补骨脂素及蛇床子素体外透皮吸收产生不同的影响

确定2%氮酮为促进剂时3种有效成分的促透效果最好。结论: 2%氮酮能够促进复方卡力孜然凝胶剂3种有效成分的有效渗透

透皮吸收过程符合Higuchi方程。

Abstract

Objective:To study on effects of in vitro percutaneous penetration of different penetration enhancers for three active ingredients from Fufang Kali Ziran gel

and to screen out effective transdermal absorption enhancers. Method:In vitro transdermal test was used by modified Franz diffusion cell method and in vitro rat skin

effect of cumulative penetration volume and penetration rate from transdermal absorption enhancers for three active ingredients(psoralen

isopsoralen and osthole) was determined by HPLC. Result:Different enhancers were found to have different degree in vitro penetration enhancing effect on psoralen

isopsoralen and osthole in Fufang Kali Ziran gel

determined 2% azone had optimum promoting effect as enhancers to three active ingredients. Conclusion:2% azone could promote effective penetration of three active ingredients from Fufang Kali Ziran gel. This process of penetration absorption could be in line with Higuchi equation.

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