Introduce the characteristic and research status for physiologically based pharmacokinetic model (PBPK). This article systemized and analysed the construction

features and application status of the PBPK model by reference 21 literatures from Pubmed. Currently

PBPK model has been widely used in the safety evaluation of toxic compounds

drug metabolism research

the influence of the drug by the enzymes and transport proteins

drug-drug interaction

and the research and development of new drugs. Although PBPK model has many advantages

and won the most encouraged evaluate results

but it need support of mathematics and computers

and cooperate of a multidisciplinary professionals

which including systems biology

medicine chemistry

pharmacology and statistic

etc

to further exploration and perfect.