Objective: To prepare wogonin albumin microspheres

and evaluate its in vitro release behavior and stability. Method: The microspheres were prepared by emulsion cross-linking method with albumin as carrier.Based on single-factor test

preparation technology of wogonin albumin microspheres were optimized by orthogonal design test

investigated size of microspheres and in vitro release property. Result: Prepared microspheres were round and surface was smooth

the average particle size was (0.95±0.14) μm

the average drug loading was (53.58±3.26)% and the average entrapment efficiency was (62.54±3.17)%

in vitro release was in line with Higuchi equation Q=10.402 8 t1/2-1.205 6 (r=0.998 2). Conclusion: This paper obtained ideal wogonin albumin microspheres

its in vitro release characteristics was in line with property of sustained-release preparation.