Feasibility of Brain Release of Asarone Hydroxypropyl--Cyclodextrin Solution Agent by Intranasal Administration

WANG Guang-ming; PAN Yan; KONG Qiu-ling; TIAN Jun

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Feasibility of Brain Release of Asarone Hydroxypropyl--Cyclodextrin Solution Agent by Intranasal Administration

更新时间：2024-01-04

- Feasibility of Brain Release of Asarone Hydroxypropyl--Cyclodextrin Solution Agent by Intranasal Administration
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 3, Pages: 16-18(2012)
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- Published：2012
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WANG Guang-ming, PAN Yan, KONG Qiu-ling, et al. Feasibility of Brain Release of Asarone Hydroxypropyl--Cyclodextrin Solution Agent by Intranasal Administration[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(3): 16-18.
DOI：

WANG Guang-ming, PAN Yan, KONG Qiu-ling, et al. Feasibility of Brain Release of Asarone Hydroxypropyl--Cyclodextrin Solution Agent by Intranasal Administration[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(3): 16-18. DOI：

摘要

目的: 探讨细辛脑羟丙基-β-环糊精溶液剂鼻腔给药脑内释药的可行性。方法: 采用家兔静脉注射细辛脑羟丙基-β-环糊精溶液剂与家兔鼻腔灌流细辛脑羟丙基-β-环糊精溶液剂相比较

探求细辛脑鼻腔给药后药物在脑内释放的可行性通路。结果: 鼻腔灌流方式血液中细辛脑质量浓度与嗅脑、大脑、筛鼻甲内的细辛脑的量

均高于静脉给药方式。结论: 细辛脑羟丙基-β-环糊精溶液剂经过筛鼻甲进入脑部这一通路过程中

药物的吸收量方面

静脉给药要小于鼻腔灌流

故细辛脑鼻腔给药脑内释药具有实践之可行性。

Abstract

Objective: To investigate feasibility of brain release of asarone hydroxypropyl-β-cyclodextrin solution agent by intranasal administration. Method:Compared injection and nasal administration perfusion in rabbit of asarone hydroxypropyl-β-cyclodextrin solution agent

feasibility pathway of drug release in brain was investigated after intranasal administration. Result:The content of asarone in blood

olfactory brain

brain and ethmoidal concha had higher quantity by nasal perfusion group than that by intravenous injection group. Conclusion: In pathway process of asarone hydroxypropyl-β-cyclodextrin solution agent enter brain by ethmoidal concha

the content of asarone was higher by nasal perfusion than injection

so it had practical feasibility of brain release by intranasal administration of asarone.

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