Objective: To study the effect of ilexgenin A on vascular endothelial growth factor(VEGF) and microvessel density(MVD) of tumor in Walker-256 rat model to explore the mechansim. Method: Thirty two Walker-256 rats were randomly divided into 4 groups

and treated with the high dose of ilexgenin A (HD group)

low dose of ilexgenin A

5-Fu (positive group)

and normal saline (NS group)

respectively. After 8 days of modeling

corresponding drugs were administered by intraperitoneal injection for 14 days. Then

blood rats werr executed to collect blood and remove tumors which were weighted

the morphological observation was performed

aspartate transaminase(AST) and alanine transaminase(ALT) levels were assayed

and the expression of VEGF and MVD in tumor was tested by immunohistochemical method. Result: In treatment group

the weight of tumor obviously decreased than that in model. In treatment group and 5-Fu

the vascular article number intensive degree

compared with model group

was obviously reduced

and ilexgenin A inhibited the elevated level of AST and ALT

the inhibition on AST level was more obvious (P<0.01)

the expression of VEGF and MVD levels was significantly decreased compared with model group (P<0.01). Conclusion: Ilexgenin A can significantly inhibit growth of tumor

the mechanism may be related to down-regulating the expression of VEGF and MVD.