Objective: To study the in vitro activity of five furanocoumarins from the root bark of Changium smyrnioides Wolff. isoimperatorin

imperatorin

xanthotoxol

phellopterin and 5-hydroxyl-8-methoxy-psoralen. Method: The antitumor effect against human liver cancer (SMMC-7721 and HepG2)

human lung cancer (A549)

human gastric cancer (MKN-45)

human uterine cervix cancer (Hela) and human breast cancer (MCF-7 and MDA-MB-231) was observed by MTT. Result: Five furanocoumarins had different inhibition on seven kinds of tumors. IC50 was from 0.30 mg·L-1 to 17.23 mg·L-1

especially isoimperatorin was most significantly effective. IC50 was from 0.39 mg·L-1 to 4.11 mg·L-1. Conclusion: These five furanocoumarins have obvious antitumor effect.