Synthesis of Lonicerin and its Protective Effect on Liver Cell Injured by Triptolide
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Synthesis of Lonicerin and its Protective Effect on Liver Cell Injured by Triptolide
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 5, Pages: 72-75(2012)
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Published:2012
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LIU Fang, SHU Ji-cheng, PAN Jing-hang, et al. Synthesis of Lonicerin and its Protective Effect on Liver Cell Injured by Triptolide [J]. Chinese journal of experimental traditional medical formulae, 2012, 18(5): 72-75.
DOI:
LIU Fang, SHU Ji-cheng, PAN Jing-hang, et al. Synthesis of Lonicerin and its Protective Effect on Liver Cell Injured by Triptolide [J]. Chinese journal of experimental traditional medical formulae, 2012, 18(5): 72-75.DOI:
Synthesis of Lonicerin and its Protective Effect on Liver Cell Injured by Triptolide
Objective: Study on the synthesis of lonicerin and its protective effect on liver cell injured by triptolide. Method: Lonicerin was synthesized with neohesperidin through dehydrogenation and demethylation by iodine and aluminum trichloride respectively and its protective effect on L02 cell injured by triptolide in vitro was evaluated by 3-(4
5)-dimethylthiahia20(-z-y1)-3
5-di-phenyterazoliumromide(MTT) assay for the first time. Result: Lonicerin was synthesized and had the protective effect on L02 cell injured by triptolide in vitro. Conclusion: The synthetic route for lonicerin with high yield was simple
feasible
economic and convenient for industrial manufacture. Lonicerin had the protective effect on L02 cell injured by triptolide.
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