Objective: To study on influence of in vivo pharmacokinetics of paeonol(Pae) from different dosages of Tiangou Jiangya capsule in rats. Method: Three dosages(low

medium

high) of TianGou Jiangya capsule (equivalent to paeonol 6.884

13.77

27.53 mg ·kg-1) were fed to rats by intragastric administration separately. Plasma samples were collected at different time and treated with methanol to precipitate protein. The contents of paeonol in plasma were determined by HPLC.Pharmacokinetic parameters between groups were statistical analyzed by SPSS 16.0. Result: Plasma concentration of paeonol was beyond minimum detection limit and plasma concentration-time curve failed to detect at low dosage group; Maximum absorption of middle and high dosages of paeonol reached the maximum absorption in 5 minute

t1/2ka

Cmax

AUC0-∞

AUC0-360

CLz/F increased significantly with increasing of intragastric administration dosages.t1/2z

MRT0-360

Vz/F reduced Significantly with increasing of intragastric administration dosages. Conclusions:Pharmacokinetics parameters of paeonol had some differences after intragastric administration of different dosages of Tiangou Jiangya capsule.