Optimization of Extraction Technology for  by Central Composite Design/Response Surface Methodology

WANG Qiu-hong; SU Yang; WU Lun; WANG Zhi-bin; YANG Bing-you; KUANG Hai-xue

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Optimization of Extraction Technology for by Central Composite Design/Response Surface Methodology

更新时间：2024-01-04

- Optimization of Extraction Technology for by Central Composite Design/Response Surface Methodology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 1, Pages: 24-27(2012)
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- Published：2012
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WANG Qiu-hong, SU Yang, WU Lun, et al. Optimization of Extraction Technology for by Central Composite Design/Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 24-27.
DOI：

WANG Qiu-hong, SU Yang, WU Lun, et al. Optimization of Extraction Technology for by Central Composite Design/Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 24-27. DOI：

摘要

目的: 采用星点设计-效应面法优选升麻中总皂苷的提取工艺。方法: 以乙醇体积分数、提取时间、溶媒比为自变量

以升麻总皂苷得率为因变量

通过对自变量各水平的多元线性回归及二项式拟合

用效应面法选取最佳工艺

同时进行预测分析。结果: 确定最优提取工艺为15倍量65%乙醇提取3次

每次170 min

提取预测值与理论值偏差0.4%

二项式拟合复相关系数r=0.988 4。结论: 星点设计-效应面法优化的升麻总皂苷提取工艺

方法简单

精密度高

可预测性较优。

Abstract

Objective: To optimize extraction process of total saponins from Cimicifuga dahurica by central composite design/response surface methodology. Method: Independent variables were ethanol concentration

reflux time and solvent fold

dependent variable was extraction rate of total saponins from C. dahurica.Level of independent variables were regressed by multiple linear and fitted by binomial.Response surface methodology was used to optimize extraction process. Prediction was carried out by comparing observed and predicted values. Result: Optimal extraction technology was:extracted 3 times by 15 times the amount of 65% ethanol with 170 min each time

deviation between observed and predicted values was 0.4%. Regression coefficients of binomial fitting complex model was as high as 0.988 4. Conclusion: This extraction process of total saponins from C. dahurica by central composite design/response surface methodology was a simple method with high precision and good predictability.

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Related Author

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Related Institution

College of Pharmacy,Heilongjiang University of Chinese Medicine

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

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College of Food and Biological Engineering，The Chongqing Engineering Laboratory for Green Cultivation and Deep Processing of the Three Gorges Reservoir Area's Medicinal Herbs， Chongqing Three Gorges University

Key Laboratory of Modern Preparation of Traditional Chinese Medicine （TCM），Ministry of Education，Jiangxi University of Chinese Medicine

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