Objective: To explore the absorption

distribution

metabdism and excretion(ADME) of baicalin from Radix Scutellariae and wuweizi ester A from Fructus Schisandrae in rats. Method: SD rats were orally administration of the extracts from Radix Scutellariae 2.5 g ·kg-1

Fructus Schisandrae 2.5 g ·kg-1

or Radix Scutellariae 2.5 g ·kg-1 with Fructus Schisandrae 2.5 g ·kg-1 once separately. Then the blood samples were collected at 0.25

1

2

4

8

12

24 h after treatment. Baicalin and wuweizi ester A were analyzed by HPLC. The data were processed with DAS 3.0 pharmacokinetic program. Result: The pharmacokinetic parameters of baicalin of Radix Scutellariae group were as follows: t1/2=(6.203±3.324)h

AUC=(41.868±28.254) μg ·L-1 ·h-1

Cmax=(2.883±0.684) μg ·L-1

MRT=(11.697±4.108) h

Vd=(568 112.69±81 364.658) L ·kg-1

CL=(98 526.569±93 774.892)L ·h-1 ·kg-1

and the Radix Scutellariae with Fructus Schisandrae group: t1/2=(10.686±1.533)h

AUC=(53.064±30.047) μg ·L-1 ·h-1

Cmax=(3.168±1.312) μg ·L-1

MRT=(16.147±1.79) h

Vd=(2 240 724.1±1 824 718.9)L ·kg-1

CL=(139 855.3±107 995.6)L ·h-1 ·kg-1. The pharmacokinetic parameters of wuweizi ester A of the Radix Scutellariae with Fructus Schisandrae group were as follows: t1/2=(21.544±14.611)h

AUC=(11.554±5.516) μg ·L-1 ·h-1

Cmax=(0.311±0.074) μg ·L-1

MRT=(34.139±18.532) h

Vd=(12 153 917±5 806 489.8)L ·kg-1

CL=(564 758.71±384 128.86) L ·h-1 ·kg-1; And the fructus schisandrae group were as follows: t1/2=(4.926±5.371)h

AUC=(4.988±3.029)μg ·L-1 ·h-1

Cmax=(0.287±0.071)μg ·L-1

MRT=(12.002±6.854)h

Vd=(3 091.656±1 585.602)L ·kg-1

CL=(615.571±250.643)L ·h-1 ·kg-1. Conclusion: The results indicated that the compatibility of Radix Scutellariae with Fructus Schisandrae can increase the blood concentration and prolong half-life of baicalin and wuweizi ester A

it may be related to the synergy protective action of Radix Scutellariae with Fructus Schisandrae on liver fibrosis.