Objective : To study the difference in fingerprints and chromatographic peak area of different batches of Huanglian Shangqing pills from different manufacturers. Method: HPLC was used to compare the difference of characteristics fingerprints of different batches of Huanglian Shangqing tablets from different or same manufacturers. The similarity was analyzed with the similarity evaluation software. Result: There were big differences in the number of peaks and peak area of Huanglian Shangqing tablets from different manufacturers. The number of peaks of different batches of Huanglian Shangqing tablets from the same manufactures were almost similar

while the contents of them existed a certain difference. Relative to the different manufacturers

the difference of the content of different batches of Huanglian shangqing tablets was smaller among the same manufacturers. Conclusion : The variation of fingerprint of Huanglian Shangqing tablets is relatively obvious among different manufacturers

but the quality of Huanglian Shangqing tablets from the same manufactures is basically stable at a certain level.