Objective: To investigate the effect of Xiaobanxia Fuling decoction and each decomposed group on the isolated gastric and duodenal smooth muscle movement of rabbit. Method: The experiment uses the organs out of body

and the biologic function analyzer to record the effect of Xiaobanxia Fuling decoction and the aqueous extract of each decomposed group on the rabbits’normal isolated gastric and duodenal smooth muscle and the contraction of isolated gastric and duodenal smooth muscle induced by Ach and atropine. The plot are collected

and the amplitude of vibration

frequency and intension of the isolated gastric and duodenal smooth muscle contraction before and after medication are compared. Result: The effect of Xiaobanxia Fuling decoction and the aqueous extract of each decomposed group on the the isolated gastric and duodenal smooth muscle movement can be recapitulated as the stomach contracts and the duodenum diastoles. It not only has effect on the normal isolated stomach and duodenum

but also has significant antagonistic effect on the rigidity and spasm of gastric and duodenal smooth muscle caused by acecoline(P<0.01); it has synergistic effect on the attenuation of the contraction of duodenal smooth muscle caused by atropine(P<0.05); and it has the effect of excitation on the smooth muscle of the fundus gastricus and the gastric antrum after the use of atropine(P<0.01). The drug potency of Xiaobanxia Fuling decoction and each decomposed group can be listed as: Xiaobanxia Fuling decoction>Xiaobanxia decoction>Rhizoma Zingiberis Recens>Rhizoma Pinelliae. Conclusion: Xiaobanxia Fuling decoction and the aqueous extract of each decomposed group has dual- effect on the isolated gastric and duodenal smooth muscle movement of rabbit; Xiaobanxia Fuling decoction is better than the decomposed group. The way that it plays the role has relationship not only with M choline receptor

but also with other regulatory factors.