Study of Antipyretic Function and Mechanism of Buzhong Yiqi Tang

LIU Jin-na; XIE Ming; GAO Xiu-lan; ZHAO Rong-hua

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Study of Antipyretic Function and Mechanism of Buzhong Yiqi Tang

更新时间：2024-01-04

- Study of Antipyretic Function and Mechanism of Buzhong Yiqi Tang
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 2, Pages: 174-176(2012)
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- Published：2012
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LIU Jin-na, XIE Ming, GAO Xiu-lan, et al. Study of Antipyretic Function and Mechanism of Buzhong Yiqi Tang[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(2): 174-176.
DOI：

LIU Jin-na, XIE Ming, GAO Xiu-lan, et al. Study of Antipyretic Function and Mechanism of Buzhong Yiqi Tang[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(2): 174-176. DOI：

摘要

目的: 探讨补中益气汤退热作用机制。方法: 雄性Wistar大鼠随机分为正常对照组、脾虚发热组、补中益气汤组共3组

每组10只。采用饮食失节+过度疲劳+注射LPS法复制脾虚发热模型。每周测体温1次。第18天开始补中益气汤组每天ig(6.83 g·kg-1)

正常组和脾虚发热组给予同体积蒸馏水

每天1次

连续5 d。第22天 AM 8:00脾虚发热组和补中益气汤2组大鼠ip脂多糖(LPS

80 μg·kg-1)诱导发热

正常组ip等体积生理盐水。测量各组大鼠ip LPS后30

120

180

220 min肛温及绘制体温曲线

测定下丘脑环磷酸腺苷(cAMP)、前列腺素E2(PGE2)。结果: 与正常对照组相比

脾虚发热组大鼠体温曲线明显上抬

各观察点体温均明显升高

下丘脑PGE2和cAMP明显升高(P<0.05或P<0.01)。与脾虚发热组比较

补中益气汤组大鼠体温曲线明显下移

下丘脑PGE2和cAMP均明显下降(P<0.05或P<0.01)。结论: 补中益气汤对脾虚发热模型大鼠具有明显的退热效用

其退热作用可能与降低中枢发热介质PGE2和cAMP有关。

Abstract

Objective: To discuss the antipyretic mechanism of Buzhong Yiqi Tang. Method: The rats were assigned into the normal group

spleen-qi deficiency with fever group

Buzhong Yiqi Tang group

10 rats in each group. The rats of spleen-qi deficiency with fever group and Buzhong Yiqi Tang group were treated with excess fatigue plus out of constant diet to copy spleen-qi deficiency rat model. The body temperatures were measured each week. From the 18th day

Buzhong Yiqi Tang group rats were fed with medicine 6.83 g·kg-1. The ones of the normal group and spleen-qi deficiency with fever group with physiological saline for 5 days. At 8:00 am on the 22th day

the rats of Buzhong Yiqi Tang group and the spleen-qi deficiency with fever group were respectively intraperitonealy injected with lipopoly saccharide(LPS

80 μg·kg-1) to induce fever. The rats of the normal group with physiological saline. The rectal temperature was measured at 30

120

180

220 min after ip LPS and the mean body temperature curve draw. Then cAMP and PGE2 in hypothalamus were measured. Result: Compared with the normal group

the rectal temperature curve of spleen-qi deficiency with fever group rises significantly at every research spot (P<0.05 or P<0.01). Compared with the spleen-qi deficiency with fever group

the temperature

cAMP and PGE2 of Buzhong Yiqi Tang group were obviously decreased(P<0.05 or P<0.01). Conclusion: Buzhong Yiqi Tang has antipyretic effect on the spleen-qi deficiency with fever model. Its antipyretic mechanism may be connected with reducing central pyrexia amboceptor PGE2 and cAMP.

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