Objective: To choose a treatment for cough variant asthma with effective drugs

to compare ketotifen with montelukast joint MeipuQing

BDP spray. Method: The inclusion criteria found 120 cases of patients. They were randomly divided into two groups(60 cases each). Two groups were treated with meipuqing kechuanning ig

and Beclomethasone Dipropionanate Aerosol as basic treatment program. Control group was also given ketotifen(1 mg

2 times a day) orally.Observation group was also given montelukast (5 mg

qn) orally. Two groups were treated for 15 weeks as a course

then to evaluate the clinical efficacy. Result: The clinical control rate was 63.33%

95.00% total efficiency in observation group. Clinical control rate of the control group 46.67%

75.00% total efficiency in control group. The difference in two groups was significantly(P<0.05). Daytime symptom scores

nighttime symptom score in the two groups were less than those before treatment 2(P<0.05); but the observation group decreased more significant than the control group

group(P<0.05). Forced expiratory volume in one second(FEV1) and FEV1% for 2 groups the difference before and after treatment were significant (P<0.05). After treatment

2 groups showed significant difference(P<0.05). The incidence of side effects in observation group was 3.33%; control group

10.00%. There was significant difference was P<0.05. Conclusion: Montelukast and ketotifen are effective for cough variant asthma treatment

the therapeutic effect of montelukast is even better.