The Effect of Zhenwu Tang on Expression of Cytokines in Rat Unilateral Ureteral Obstruction Model
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The Effect of Zhenwu Tang on Expression of Cytokines in Rat Unilateral Ureteral Obstruction Model
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 3, Pages: 164-168(2012)
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Published:2012
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HAN Ling, LI Sha-sha, FENG Sen-ling, et al. The Effect of Zhenwu Tang on Expression of Cytokines in Rat Unilateral Ureteral Obstruction Model[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(3): 164-168.
DOI:
HAN Ling, LI Sha-sha, FENG Sen-ling, et al. The Effect of Zhenwu Tang on Expression of Cytokines in Rat Unilateral Ureteral Obstruction Model[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(3): 164-168.DOI:
The Effect of Zhenwu Tang on Expression of Cytokines in Rat Unilateral Ureteral Obstruction Model
Objective: To explore the molecular immunologe mechanisms of Zhenwu Tang for protecting kidney from injury. Method: Rats were randomly divided into 5 groups
in addition to the normal group
the remaining rats were operated for unilateral ureteral obstruction model(UUO)
and then losartan (20 mg ·kg-1)
Zhenwu Tang low and high dose (crude drug 2.1
9.8 g ·kg-1) were administered
respectively. Model group and control group were given saline. Serum were collected at day 29 after UUO modeling
and the cytokines including monocyte chemoattractant protein-1(MCP-1)
plasminogen activator inhibitor-1(PAI-1)
tumor necrosis factor-α(TNF-α)
interleukin-1β(IL-1β)
IL-6 and adiponectin: were detected by multiple cytokine luminex detection. Result: The serum content of MCP-1
PAI-1
and IL-6 in UUO model was significantly higher compared with normal rats. The serum content of Adiponetin TNF-α
and IL-1β was no significantchange. Zhenwu Tang can significantly reduce elevated blood PAI-1
IL-6
MCP-1 levels. Conclusion: The molecular mechanism of Zhenwu Tang in remission of renal interstitial firosis may be related to reduce serum MCP-1
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