Anti-diabetic Effect of Aqueous Extract from in Type 2 Diabetic Rats
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Anti-diabetic Effect of Aqueous Extract from in Type 2 Diabetic Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 7, Pages: 216-219(2012)
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Published:2012
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YAN Zhe-lin, DONG Zheng-ping, SUN Wen, et al. Anti-diabetic Effect of Aqueous Extract from in Type 2 Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(7): 216-219.
DOI:
YAN Zhe-lin, DONG Zheng-ping, SUN Wen, et al. Anti-diabetic Effect of Aqueous Extract from in Type 2 Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(7): 216-219.DOI:
Anti-diabetic Effect of Aqueous Extract from in Type 2 Diabetic Rats
Objective: To observe the effects of aqueous extract from Potentilla discolor Bunge (APB) on blood glucose and lipids level in type 2 diabetic rat model. Method: Three week-old Wistar male rats were divided randomly into two groups according to random data table: control group with rat standard diet and model group with high-fat diet (HFD)for 16 weeks in order to induce insulin resistance and type 2 diabetic model
the HFD group was intraperitonealy given small dose STZ. Then
the model rats were divided into 4 groups: model group
positive control group (pioglitazone 4.05 mg·kg-1)
high-dose group (400 mg·kg-1) and low dose group (200 mg·kg-1) of APB aqueous extract
7 rats in each group. The control group and model group were fed with distilled water at 10 mL·kg-1. After 4 weeks of drug intervention
the fasting blood glucose (FBG)
serum triglyceride (TG)
serum total cholesterol (TC)
serum free fatty acid (FFA)
serum low-density lipoprotein (LDL-C) and serum high density lipoprotein (HDL-C) were examined. Result: Both the aqueous extract and the pioglitazone group significantly decreased FBG
TG
TC
LDL and FFA level
and increased the HDL level(P<0.05). Conclusion: Aqueous extract of P. discolor may offer an alternate treatment for diabetes by regulating fasting blood glucose and serum lipids levels in type 2 diabetic insulin resistance rats.