Inhibiting Proliferation of Human Embro Fibroblasts by Curcumol

ZHU Xing; YANG Chang-fu

您当前的位置：

首页 >

文章列表页 >

Inhibiting Proliferation of Human Embro Fibroblasts by Curcumol

更新时间：2024-01-04

- Inhibiting Proliferation of Human Embro Fibroblasts by Curcumol
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 1, Pages: 226-228(2012)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012
- 稿件说明：
移动端阅览
ZHU Xing, YANG Chang-fu. Inhibiting Proliferation of Human Embro Fibroblasts by Curcumol[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 226-228.
DOI：

ZHU Xing, YANG Chang-fu. Inhibiting Proliferation of Human Embro Fibroblasts by Curcumol[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 226-228. DOI：

摘要

目的: 探讨莪术醇对人胚肺成纤维细胞增殖抑制作用。方法: MTT法观察莪术醇对人胚肺成纤维细胞增殖的抑制作用;天狼猩红染色法测定细胞胶原的分泌能力

流式细胞术检测细胞周期时相分布。结果: 50~200 mg ·L-1莪术醇作用细胞后能抑制人胚肺成纤维细胞的增殖和制胶原沉积

以96 h效果最为明显

并阻滞细胞停滞于G0/G1期

降低S期和G2/M期细胞时相比例。结论: 莪术醇通过将细胞周期阻滞于G0/G1

减少DNA复制

抑制人胚肺成纤维细胞增殖和细胞分泌胶原。

Abstract

Objective: To explore the inhibiting the proliferation and the mechanism of human embro fibroblasts (MRC-5) by curcumol. Method: The effects of curcumol on the proliferation of MRC-5 were determined by MTT assay. The cotents of collagen accumulated were determined by the optical density at 540 nm of picro-sirius red staining. The cell cyclic retardation was examined by using flowcytometry. Result: MTT showed that curcumol(50-200 mg ·L-1) had an inhibitory effect on the proliferation and had reduced collagen of secretion in MRC-5. The better time in the 96 hour. The cell cycle analysia showed that curcumol(50-200 mg ·L-1) increased the percentage of G0/G1 phase cells

updown the percentage of S and G2/m phase cells. Conclusion :Curcumol can increase the percentage of G0/G1 phase cells

delay cell replication

inhibit the proliferation and collagen of secretion of MRC-5.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Mechanism of Traditional Chinese Medicine Regulating JAK/STAT Signaling Pathway to Intervene in Lung Cancer： A Review

Inhibitory Effect of Sophora alopecuroides Total Alkaloids and Two Monomer Alkaloids on PC12 Cell Activity

Effect of Qiling Baitouweng Tang on Proliferation and Apoptosis in Diffuse Large B-cell Lymphoma Through JAK2/STAT3 Signaling Pathway

Anti-tumor Effect of Chinese Medicine by Inducing Cell Cycle Arrest： A Review

Systems Pharmacology-based Analysis of Anti-tumor Mechanism of Houttuynia cordata

Related Author

CAO Jiarui

FENG Bo

MA Chunzheng

CHEN Weixia

YU Jiangfan

CAO Shasha

ZHANG Zhenyu

OUYANG Wenhui

Related Institution

Henan Province Hospital of Traditional Chinese Medicine/The Second Affiliated Hospital of Henan University of Chinese Medicine

The Second Clinical Medical College， Henan University of Chinese Medicine

Xinjiang Key Laboratory of Uighur Medical Prescription，Xinjiang Institute of Traditional Uighur Medicine

Affiliated Hospital of Nanjing University of Chinese Medicine， Jiangsu Province Hospital of Chinese Medicine

The First School of Clinical Medicine of Nanjing University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰