Intervention Effects of Tangpingjian on Inflammatory Cytokines in Rats with Diabetes Mellitus Type 2
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Intervention Effects of Tangpingjian on Inflammatory Cytokines in Rats with Diabetes Mellitus Type 2
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 21, Pages: 235-237(2011)
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Published:2011
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ZHANG Yong-peng, LIU Jing, JIN Guo-yin, et al. Intervention Effects of Tangpingjian on Inflammatory Cytokines in Rats with Diabetes Mellitus Type 2[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(21): 235-237.
DOI:
ZHANG Yong-peng, LIU Jing, JIN Guo-yin, et al. Intervention Effects of Tangpingjian on Inflammatory Cytokines in Rats with Diabetes Mellitus Type 2[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(21): 235-237.DOI:
Intervention Effects of Tangpingjian on Inflammatory Cytokines in Rats with Diabetes Mellitus Type 2
Objective: To investigate the effects of Tangpingjian(TPJ) on insulin resistance(IR) and serum Adiponectin (Adip)
leptin
tumor necrosis factor alpha(TNF-α) in type 2 diabetic(T2DM) rats. Method: The type 2 diabetic rats model was established by the injection of small-dose streptozotocin (STZ 30 mg·kg-1) combined with high-energy feeding. The rats were randomly assigned to the model group
TPJ high-dose
TPJ small dose group and normal control groups. Rats in TPJ high-dose group were performed intragastric administration of 14.4 g·kg-1·d-1 crude drug of Tangpingjian
and rats in TPJ small dose group were administrated with 7.2 g·kg-1·d-1 crude drug of Tangpingjian
the other two groups were administrated with distilled water by equal volume. All four groups had been treated for four weeks. Fasting blood-glucose (FBG)
Fasting insulin(FINS)
TNF-α
Adip and Leptin of rats were measured after four weeps. Calculation of insulin sensitivity index was carried out(IAI). Result: TPJ could decrease FBG
FINS
leptin and TNF-α remarkably
and improve insulin sensitivity index and Adip activity obviously in experimental rats. It has remarkable difference compared with model group (P<0.01
P<0.05). Conclusion: TPJ can improve T2DM rat inflammatory response