Anti-inflammatory Effect of Jianghuang Xiaocuo Chaji

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Anti-inflammatory Effect of Jianghuang Xiaocuo Chaji

更新时间：2024-01-04

- Anti-inflammatory Effect of Jianghuang Xiaocuo Chaji
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 19, Pages: 219-221(2011)
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- Published：2011
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CHEN Niao-niao. Anti-inflammatory Effect of Jianghuang Xiaocuo Chaji[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 219-221.
DOI：

CHEN Niao-niao. Anti-inflammatory Effect of Jianghuang Xiaocuo Chaji[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 219-221. DOI：

摘要

目的: 研究姜黄消痤搽剂的抗炎机制。方法: 注射卵白蛋白(ovalbumim

OA)致小鼠足肿胀

观测姜黄消痤搽剂1.35

0.90

0.45 mg·kg-1外用

3次/d

连续4 d

对OA引起足肿胀的影响

检测炎症组织中前列腺素E2(PGE2)的含量;福氏完全佐剂(FCA)致大鼠关节炎

1.35

0.90

0.45 mg·kg-1外用

2次/d

连续30 d

检测致炎部位皮肤和皮下组织的病理改变和白细胞介素(IL-2)含量。结果: 姜黄消痤搽剂可显著抑制OA引起足肿胀

并能降低炎症组织中PGE2的含量;对OA致敏激发皮炎皮损组织有明显治疗作用;可减轻FCA所致炎症反应并降低炎症组织中IL-2的含量。结论: 姜黄消痤搽剂可能通过抑制PGE2

IL-2的产生而发挥抗炎作用。

Abstract

Objective: To study the anti-inflammatory effect of Jianghuang Xiaocuo Chaji. Method: Anti-inflammatory effect of Jianghuang Xiaocuo Chaji was studied on various experimental models. Result: Jianghuang Xiaocuo Chaji (1.35

0.90

0.45 mg·kg-1

externally used three times daily for 4 d) inhibited mice paw edema produced by ovalbum and reduced the production of prostaglandin-2(PGE2) in inflammatory tissues. In allergic arthritis mice

Jianghuang Xiaocuo Chaji (1.35

0.90

0.45 mg·kg-1 externally used twice daily for 30 d) could inhibit the dermal pathological changes and decrease the content of serum interleukin-2(IL-2). Conclusion: Jianghuang Xiaocuo Chaji showed remarkable antiinflammatory effects

reduced the production of PGE2 and decreased the content of serum IL-2.

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