Preparation and Quality Control of Breviscapine Gel

FANG Rui; WANG Cheng-fang; LIU Zi-mu; FEI Chao; DU Shu-shan

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Preparation and Quality Control of Breviscapine Gel

更新时间：2024-01-04

- Preparation and Quality Control of Breviscapine Gel
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 24, Pages: 52-55(2011)
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- Published：2011
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FANG Rui, WANG Cheng-fang, LIU Zi-mu, et al. Preparation and Quality Control of Breviscapine Gel[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24): 52-55.
DOI：

FANG Rui, WANG Cheng-fang, LIU Zi-mu, et al. Preparation and Quality Control of Breviscapine Gel[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24): 52-55. DOI：

摘要

目的 :制备灯盏花素凝胶剂

并以野黄芩苷含量、凝胶pH等为质量控制指标

建立质量控制方法。方法 :以灯盏花素为主药

卡波姆940等为基质

制备灯盏花素凝胶剂。对其性状进行评价

测量pH

建立高效液相色谱法测定野黄芩苷含量的方法

并进行初步稳定性研究。结果 : 灯盏花素凝胶剂性状稳定、pH在6.00~7.00

符合2010年版《中国药典》规定

凝胶中野黄芩苷含量不少于8 mg·g-1

且初步稳定性良好

可长期存放。结论 :灯盏花素凝胶剂的质量稳定

控制方法简便可行

结果准确可靠

重复性好

可作为本制剂的质控标准。

Abstract

Objective: To prepare breviscapine gel and use scutellarin content and pH as the major effective index to establish an accurate method for its quality control. Method : The gel was prepared by taking breviscapine as main component and carbopol as materia1.Valuation the gel with appearance and pH. The content of the component in the gel was determined by HPLC. Result : The properties is stabilization

pH between 6.00-7.00 all in line with the rules of The Pharmacopoeia of PRC(2010)

content of scutellarin in breviscapine gel is above 8 mg·g-1. Moreover

the gel was uniformity and stability. Conclusion : The method is simple

reliable and accurate

and can be used for the quality control of breviscapine gel.

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Related Institution

College of Pharmacy, Hunan Provincial Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Laboratory of Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine

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School of Life Science and Biopharmceutics,Shenyang Pharmaceutical University

Institute of Chinese Material Medicine,China Academy of Chinese Material Science

Tianjin University of Traditional Chinese Medicine

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