Experimental Study on Different Extracts Xiongma Decoction on Reserpine Induced Migraine Model

ZENG Gui-rong; MA Li; GUO Jian-sheng; WANG Qiang

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Experimental Study on Different Extracts Xiongma Decoction on Reserpine Induced Migraine Model

更新时间：2024-01-04

- Experimental Study on Different Extracts Xiongma Decoction on Reserpine Induced Migraine Model
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 24, Pages: 162-164(2011)
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- Published：2011
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ZENG Gui-rong, MA Li, GUO Jian-sheng, et al. Experimental Study on Different Extracts Xiongma Decoction on Reserpine Induced Migraine Model[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24): 162-164.
DOI：

ZENG Gui-rong, MA Li, GUO Jian-sheng, et al. Experimental Study on Different Extracts Xiongma Decoction on Reserpine Induced Migraine Model[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24): 162-164. DOI：

摘要

目的 : 观察芎麻汤不同提取物治疗偏头痛的药理作用。方法 :采用小鼠皮下注射1 mg·kg-1利血平致小鼠偏头痛模型、醋酸致小鼠扭体模型

昆明小鼠随机分为阿米替林组(0.033 g·kg-1)、芎麻汤水提液组(1.4

5.6 g·kg-1)、芎麻汤醇提组(1.4

5.6 g·kg-1)、芎麻汤挥发油组(1.4

5.6 g·kg-1)

连续给药7 d

观察芎麻汤水提液

挥发油、醇提液对偏头痛模型小鼠血清5-羟色胺(5-HT)含量及镇痛作用的影响。结果 : 芎麻汤水提液(5.6 g·kg-1)能明显升高利血平化低5-HT小鼠模型血清中5-HT的含量(P<0.01)

芎麻汤挥发油(1.4

5.6 g·kg-1)能明显延长冰醋酸致小鼠扭体潜伏期及减少扭体次数。结论 : 芎麻汤水提液对偏头痛小鼠模型有一定的作用

芎麻汤挥发油具有一定的镇痛作用。

Abstract

Objective : To observe effects of different extracts from Xiongma decoction on migraine. Method : The mice migraine model was induced by

reserpin and acetic acid was used to induce mice writhing model. Mice were injected 1 mg·kg-1 reserpine to induce migraine model. Mice were randomly divided into amitriptyline group (0.033 g·kg-1)

extract group of Xiongma decocotion (1.4

5.6 g·kg-1)

alcohol extract group of Xiongma decoction(1.4

5.6 g·kg-1)

volatile oil group (1.4

5.6 g·kg-1)

which were orally given for 7 days. The level of 5-HT and analgesic effect were observed. Result : The extracts from Xiongma decoction significantly increased 5-HT level (P <0.01). Volatile oil extract can significantly prolong the incubation period of acetic acid induced writhing and twisting frequency (P <0.05). Conclusion : Extracts of Xiongma decoction have a certain effect on mice migraine model and an analgesic effect.

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Related Author

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Related Institution

Xiyuan Hospital， China Academy of Chinese Medical Sciences

Third Affiliated Hospital of Liaoning University of TCM

Liaoning University of Traditional Chinese Medicine（TCM）

State Key Laboratory of Bioactive Substances and Function of Natural Medicine，Institute of Materia Medica， Chinese Academy of Medical Sciences and Peking Union Medical College

The Affiliated Hospital of Shaanxi University of Chinese Medicine

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