Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 24, Pages: 247-251(2011)
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Published:2011
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QU Yan-ge, Chen Jun, CAI Bao-chang. Advances on Studies of Strychnine[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24): 247-251.
DOI:
QU Yan-ge, Chen Jun, CAI Bao-chang. Advances on Studies of Strychnine[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24): 247-251.DOI:
Strychnine is one of the main active and toxic ingredients in a Chinese medicine
Semen Strychni
which was found nearly two hundred years ago. In this article
we summarized the progress on studies of the activities、toxicology、pharmacodynamics and main metabolites of strychnine.The strychnine poisoning is mainly due to paralysis because of spinal cord over-excitation and hypoxia. The strychnine has effects on nervous system such as the spinal cord
the medulla oblongata and digestive system. Pharmacokinetic studies reveal its absorption
tissue distribution and metabolism.the paper can provide reasonable theory basis for the in-depth study of the strychnine and clinical application.